The effect of assortative mating upon genetic association studies: spurious associations and population substructure in the absence of admixture

Behavior Genetics
David T Redden, David B Allison

Abstract

Spurious associations due to confounding factors are an often cited and intensely debated concern for genetic association studies. Great attention has been focused upon the specific threat of confounding due to population stratification. This emphasis has spurred the development of many statistical genetic methods to detect and correct for the potentially confounding effects of admixture. Unfortunately, this emphasis on admixture has led some authors to suggest that if ethnically homogenous populations are used, spurious associations are unlikely to occur. We show that under small and realistic degrees of assortative mating over time, spurious associations arise even in ethnically homogeneous populations. We demonstrate that structured association and genomic control tests can, under certain conditions, correct for these spurious associations. We conclude that investigators should not assume spurious associations will not occur in association studies using ethnically homogenous populations and recommend the use of genomic control methods and/or family-based association tests within genetic association studies.

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Citations

Apr 17, 2009·The New England Journal of Medicine·Kevin R VielTom E Howard
Nov 26, 2009·Genome Biology·Neil RischEsteban Gonzalez Burchard
May 15, 2013·The American Naturalist·Yuexin JiangMark Kirkpatrick
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Nov 18, 2017·Scientific Reports·Xiaoyin LiXiaofeng Zhu
Mar 21, 2019·Proceedings. Biological Sciences·Claire Dandine-RoullandRaphaëlle Chaix
Apr 10, 2007·Psychiatric Genetics·Mary M Robertson, Andrea E Cavanna
Jan 20, 2007·Human Reproduction·Charlotte WangChuhsing Kate Hsiao
Oct 5, 2019·Bio Systems·Akihiro NishiNicholas A Christakis
Nov 7, 2021·Translational Psychiatry·Tim T MorrisNeil M Davies
Nov 24, 2021·Biology Letters·Thomas M M VersluysVincent Savolainen

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