The effect of asthma therapeutics on signalling and transcriptional regulation of airway smooth muscle function

Pulmonary Pharmacology & Therapeutics
Alaina J AmmitSuzanne Zuyderduyn

Abstract

Our knowledge of the multifunctional nature of airway smooth muscle (ASM) has expanded rapidly in the last decade, but the underlying molecular mechanisms and how current therapies for obstructive airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), affect these are still being elucidated. Our current knowledge has built on the pharmacology of human ASM contraction and relaxation established prior to that and which is reviewed in detail elsewhere in this issue. The advent of methods to isolate and culture ASM cells, especially human ASM cells, has made it possible to study how they may contribute to airway remodelling through their synthetic, proliferative, and migratory capacities. Now the underlying molecular mechanisms of ASM growth factor secretion, extracellular matrix (ECM) production, proliferation and migration, as well as contraction and relaxation, are being determined. A complex network of signalling pathways leading to gene transcription in ASM cells permits this functional plasticity in healthy and diseased airways. This review is an overview of the effects of current therapies, and some of those in development, on key signalling pathways and transcription factors involved in these ASM ...Continue Reading

References

Sep 1, 1992·American Journal of Respiratory Cell and Molecular Biology·J C MakP J Barnes
Jan 1, 1991·General Pharmacology·B M NabishahB A Khalid
May 19, 1989·European Journal of Pharmacology·J C Mak, P J Barnes
Oct 1, 1994·Pflügers Archiv : European journal of physiology·D FranziusR Penner
May 1, 1996·American Journal of Respiratory and Critical Care Medicine·A WoolcockL A Jacques
Dec 1, 1995·British Journal of Pharmacology·A G StewartP R Tomlinson
Nov 1, 1996·British Journal of Pharmacology·C M Schramm, M M Grunstein
Nov 1, 1996·The Journal of Allergy and Clinical Immunology·E W Alton, A A Norris
Aug 13, 1998·The European Respiratory Journal·Luke J JanssenP A Betti
Nov 26, 1999·American Journal of Respiratory Cell and Molecular Biology·Alaina J AmmitReynold A Panettieri
Jun 14, 2000·The Journal of Biological Chemistry·C E HeiseJilly F Evans
Oct 6, 2000·American Journal of Respiratory Cell and Molecular Biology·Vera P KrymskayaRaymond B Penn
Mar 20, 2001·American Journal of Respiratory and Critical Care Medicine·N J VanackerR A Pauwels
May 5, 2001·Expert Opinion on Pharmacotherapy·M E Krawiec, S E Wenzel
May 26, 2001·The Journal of Endocrinology·P DeleriveB Staels
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alan J KnoxL Pang
Jan 10, 2002·American Journal of Respiratory and Critical Care Medicine·William R HendersonEmil Y Chi
Jan 31, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jochen J RüdigerLutz-Henning Block
May 15, 2002·The Biochemical Journal·Dipak P Ramji, Pelagia Foka
Sep 3, 2002·American Journal of Respiratory and Critical Care Medicine·Krishnan ParameswaranPaul M O'Byrne
Oct 25, 2002·American Journal of Respiratory Cell and Molecular Biology·Andor R KranenburgHari S Sharma
Nov 29, 2002·American Journal of Respiratory and Critical Care Medicine·Carlos A CamargoTheodore F Reiss
Dec 28, 2002·American Journal of Respiratory and Critical Care Medicine·Janette K BurgessJudith L Black
Feb 11, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stephen M CarlinJudith L Black
Feb 18, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Simonetta BaraldoStephanie A Shore
Feb 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Elena A GoncharovaReynold A Panettieri
Mar 5, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A Y WuW Li
Jul 12, 2003·American Journal of Respiratory Cell and Molecular Biology·Susan Potter-PerigoThomas N Wight
Nov 25, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Altaf S KaziAili L Lazaar
Dec 6, 2003·The American Journal of Medicine·Aili L Lazaar, Reynold A Panettieri
Jan 27, 2004·American Journal of Respiratory and Critical Care Medicine·Krishnan ParameswaranPaul M O'Byrne
Mar 3, 2004·British Journal of Pharmacology·Reinoud GosensHerman Meurs
Apr 15, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Valérie Capra
Apr 22, 2004·The Journal of Allergy and Clinical Immunology·Peter R A JohnsonJudith L Black
Aug 17, 2004·The Journal of Allergy and Clinical Immunology·S J HirstAlastair G Stewart
Feb 8, 2005·American Journal of Respiratory and Critical Care Medicine·Reinoud GosensHerman Meurs
Mar 24, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S J McMillanC M Lloyd
Apr 12, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Deepak A DeshpandeMathur S Kannan
Aug 27, 2005·American Journal of Respiratory Cell and Molecular Biology·Jie ZhuPeter K Jeffery
Sep 24, 2005·American Journal of Respiratory and Critical Care Medicine·Peter R A JohnsonJudith L Black
Nov 3, 2005·Paediatric Respiratory Reviews·Malcolm Johnson
Mar 2, 2006·The European Respiratory Journal·D DusserP Iacono
Apr 6, 2006·Biological & Pharmaceutical Bulletin·Tsutomu YamazakiToshio Kishimoto
May 19, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Garth PowisD Lynn Kirkpatrick
Sep 5, 2006·The Journal of Allergy and Clinical Immunology·Janette K BurgessJudith L Black
Sep 13, 2006·British Journal of Pharmacology·John V BonacciAlastair G Stewart
Oct 6, 2006·The Journal of Pharmacology and Experimental Therapeutics·Kazuhiro ItoIan M Adcock
Oct 13, 2006·The Journal of Allergy and Clinical Immunology·Yoshiko Ogawa, William J Calhoun
Dec 21, 2006·Journal of the National Cancer Institute·Thiruvengadam ArumugamCraig D Logsdon
Mar 10, 2007·The Journal of Pharmacology and Experimental Therapeutics·Masakazu HirakawaMasahiro Oike
May 1, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shaoping XieKian Fan Chung
May 17, 2007·The European Respiratory Journal·D J PowrieJadwiga Anna Wedzicha
Jul 7, 2007·Immunology·David A Medina-TatoMalcolm L Watson
Aug 29, 2007·Muscle & Nerve·Maria Julia MarquesHumberto Santo Neto
Sep 1, 2007·Respiratory Medicine·Frank BühlingTobias Welte
Nov 13, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Pawan SharmaAndrew J Halayko
Dec 21, 2007·Proceedings of the American Thoracic Society·William T Gerthoffer
Feb 5, 2008·European Journal of Pharmacology·Mirella ProfitaMark Gjomarkaj

Citations

Jul 9, 2014·Expert Review of Clinical Immunology·Jean-Christophe Bérubé, Yohan Bossé
Jul 3, 2015·Expert Review of Respiratory Medicine·Zhi LiaoXia He
Sep 10, 2019·British Journal of Pharmacology·Giovanna De CuntoFiorentina Roviezzo
Nov 16, 2011·Expert Review of Respiratory Medicine·Cynthia J Koziol-WhiteReynold A Panettieri
Mar 16, 2013·American Journal of Respiratory and Critical Care Medicine·Ching Yong YickPeter J Sterk

Related Concepts

Adrenergic beta-Agonists
Asthma
Vicrom
Polychemotherapy
Glucocorticoid Effect
Smooth Muscle
Respiratory Tract Structure
Transcription Factor
Signal Transduction
Gene Activation

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Basement Membranes

Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Related Papers

Respiratory Physiology & Neurobiology
Stephanie A Shore, Paul E Moore
American Journal of Respiratory and Critical Care Medicine
V M KeatingsPeter J Barnes
© 2021 Meta ULC. All rights reserved