The Effect of Atorvastatin on Preventing Noise-Induced Hearing Loss: An Experimental Study

The International Journal of Occupational and Environmental Medicine
L JahaniZ Razmjooei

Abstract

Noise-induced hearing loss (NIHL) is a common, irreversible occupational disease. Statins have recently been proposed to prevent NIHL. To assess the effect of atorvastatin for the prevention of NIHL in rats. In this experimental study, forty 2-3-month-old Wistar male rats were divided into 5 groups of 8 animals. 3 groups of rats received atorvastatin at doses of 5, 25, and 50 mg/kg daily for 14 days. The 4th group of rats received normal saline; another group was the control group. After 2 weeks of treatment, the rats were exposed to broad-band noise (125-20 000 Hz) at 110 dB-SPL intensity for 2 hours. Response amplitude of all ears at 5 frequencies was assessed by distortion product otoacoustic emissions (DP-OAE) at baseline, 2 hours, and 2 weeks after the exposure. Response amplitude was significantly decreased at all frequencies immediately after exposure to noise in all studied groups. The amplitude increased after 72 hours to a level higher than temporary threshold shift (TTS); this change was only significant in the group received 5 mg/kg atorvastatin. Low dose atorvastatin (5 mg/kg) used before exposure to noise can probably prevent NIHL in rats. This effect was not observed with higher doses of the drug.

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Citations

May 26, 2017·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Trung N LeBrian Westerberg
Oct 27, 2018·Assay and Drug Development Technologies·Hermann A M Mucke
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Jun 6, 2017·Journal of Korean Medical Science·Farrokh Habibzadeh
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Jan 5, 2021·The Journal of Clinical Investigation·Katharine A FernandezLisa L Cunningham
Sep 13, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Yun Yeong LeeYun-Hoon Choung

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