The effect of atropine and metiamide on pepsin secretion of the rat

Agents and Actions
I Szelenyi, H Engler

Abstract

The inhibition of pepsin secretion by metiamide and atropine was studied by perfusing the stomach lumen of anaesthetized rats. Atropine was more effective than metiamide in the inhibition of pepsin secretion induced by pentagastrin or carbachol. Perfusion of the stomach with a weak acid solution stimulated pepsin secretion, which was only abolished by atropine. Metiamide was ineffective. It is postulated that (1) hydrogen ions probably stimulate pepsin secretion, (2) a cholinergic-like reflex may be involved in this stimulation, (3) anticholinergics are direct and strong inhibitors of pepsin secretion, (4) histamine H2-receptor antagonists probably inhibit pepsin secretion indirectly via reduction of acid output.

References

Aug 24, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·J Puurunen, E Westermann
Jun 1, 1979·Agents and Actions·K T BunceF R Matheson
Apr 15, 1979·European Journal of Pharmacology·J Puurunen
Jul 1, 1975·The American Journal of Digestive Diseases·T E Bynum, L R Johnson
Apr 21, 1972·Nature·J W BlackE M Parsons
Jun 1, 1974·British Journal of Pharmacology·P K DebnathA K Sanyal
Oct 1, 1972·The American Journal of Physiology·L R Johnson
Sep 1, 1974·Scientific American·L L Cavalli-Sforza
May 1, 1971·The American Journal of Digestive Diseases·L R Johnson
Jun 1, 1962·The Journal of Physiology·V M ROSENOER, H O SCHILD

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Citations

Feb 1, 1983·The Journal of Pharmacy and Pharmacology·M E ParsonsD Wintermeyer

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