PMID: 8590257Jan 1, 1995Paper

The effect of aurintricarboxylic acid, an endonuclease inhibitor, on ischemia/reperfusion damage in rat retina

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
T T LamM O Tso

Abstract

Apoptosis is a form of cell death distinct from necrosis showing distinctive morphologic features and may require energy. It is under various control mechanisms and may involve an endonuclease, which cleavages genomic DNA in the internucleosomal linker regions. Previously, we reported that ischemic/reperfusion injury to rat retina induced endonuclease mediated apoptosis of retinal neurons. In this study, we examined the effect of aurintricarboxylic acid (ATA), an endonuclease inhibitor, on ischemia/reperfusion damage in rat retina in our established rat model. A single intraperitoneal injection of ATA at 2 mg/kg given immediately after 60 minutes of ischemia to the retina showed no observable effect. At 10 mg/kg, there was notable beneficial effect morphologically but not morphometrically. ATA at 100 mg/kg showed significant effect both morphologically and morphometrically. This observation is consistent with the hypothesis that endonuclease mediated apoptosis may be involved in retinal cell loss after ischemia/reperfusion insult.

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Citations

Feb 10, 2004·Progress in Retinal and Eye Research·Neville N OsborneJosé Melena
Jul 23, 1999·Survey of Ophthalmology·N N OsborneM S Nash
Aug 5, 2000·Progress in Retinal and Eye Research·P Heiduschka, S Thanos
Oct 20, 1998·Progress in Retinal and Eye Research·C E ReméA Wenzel
Feb 5, 1999·Progress in Retinal and Eye Research·R LindenL B Chiarini
Jul 17, 2003·Journal of Postgraduate Medicine·S KaushikJ Ram
Dec 22, 2010·Indian Journal of Ophthalmology·Sushil K VasudevanJonathan G Crowston
May 25, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Kishor Devalaraja-NarashimhaBabu J Padanilam
Apr 1, 1997·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·T T LamM O Tso
Sep 1, 2007·Clinical & Experimental Ophthalmology·Zeynep AktaşBerati Hasanreisoğlu
Aug 1, 1997·Acta Ophthalmologica Scandinavica·J Caprioli

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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