The effect of Baicalein on hippocampal neuronal damage and metalloproteinase activity following transient global cerebral ischaemia

Phytotherapy Research : PTR
Jung-Hyun Lee, Seong-Ryong Lee

Abstract

Baicalein, a flavonoid derived from Scutellaria baicalensis Georgi, is known to protect neural tissue from damage. Several studies have found that baicalein reduces brain infarction following focal brain ischaemia. However, there are few reports on the protective effects of baicalein following global brain ischaemia. Therefore, the current study was designed to address the effects of baicalein on neuronal damage and matrix metalloproteinase (MMP; gelatinase) activity in the hippocampus after transient global ischaemia. C57BL/6 mice were subjected to transient global brain ischaemia for 20 min and sacrificed 72 h after ischaemic insult. Baicalein (200 mg/kg, once daily, as a suspension in 0.5% carboxymethylcellulose) or an equal volume of vehicle was orally administered to the mice from 7 days prior to the ischaemic insult until sacrifice. After global ischaemia neuronal damage was significant in CA1 and CA2 pyramidal cell layers. In baicalein-treated mice, neuronal damage from the ischaemic insult was significantly less than that in vehicle-treated mice. Baicalein administration also inhibited MMP-9 activity in the hippocampus. These data demonstrate that baicalein reduces hippocampal neuronal damage after transient global isch...Continue Reading

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Citations

Mar 30, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Hsiao-Ming ChaoFang-Ping Chao
Apr 23, 2014·Chinese Journal of Integrative Medicine·Bhakta Prasad GaireHocheol Kim
Jul 5, 2013·Phytotherapy Research : PTR·Barbara RomanoFrancesca Borrelli
Apr 23, 2013·Behavioural Brain Research·Lígia Mendes SoaresRúbia Maria Weffort de Oliveira
Dec 2, 2014·International Journal of Molecular Medicine·Ji-Hong Moon, Sang-Youel Park
Oct 21, 2015·European Journal of Pharmacology·Wen-Xia ZhengXia-Min Hu
Sep 20, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kandhasamy SowndhararajanSongmun Kim
Apr 10, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Johanna Seitz-HollandMarek Kubicki
May 28, 2019·Current Medicinal Chemistry·Ze WangJing-Shan Shi

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