PMID: 6159834May 1, 1980Paper

The effect of barbiturates on 24-h water intake and renal excretion of sodium and water in dogs

Archives internationales de physiologie et de biochimie
J Sobocińska, E Szczepańska-Sadowska

Abstract

The effects of barbiturates on 24-h intakes of water and food and urinary excretion of sodium and potassium as well as on plasma concentration of sodium and potassium and osmolality were examined in dogs placed in metabolism cages and fed with a semiliquid diet. Administration of barbiturates stimulated drinking in a Series of 8 dogs having free access to water. Twenty four-h water intake and water balance increased significantly. Food intake, urinary output and urinary excretion of solutes, sodium and water did not change in this Series. A significant decrease in urine output as well as in osmolal clearance and urinary excretion of sodium was observed in a Series of 7 dogs having water restricted for 24 h following administration of barbiturates. Water balance increased in this Series. The same restriction of water in the dogs which had not received barbiturates did not modify renal excretion of water and electrolytes. Plasma osmolality, sodium and potassium concentrations did not change in either Series of experiments. It is concluded that barbiturates induce positive water balance either by stimulation of drinking when water is freely available or by reduction in urine output when water is restricted. The results suggest tha...Continue Reading

References

Mar 1, 1978·The Journal of Physiology·J T FitzsimonsG Richards
Mar 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·W A PettingerS N Brooks
Apr 1, 1970·The American Journal of Physiology·J P Bonjour, R L Malvin
Apr 1, 1972·Physiological Reviews·J T Fitzsimons
May 1, 1963·The American Journal of Physiology·H SCHMIDT, L DRY
Apr 1, 1955·Journal of Comparative and Physiological Psychology·L I O'KELLY, H H WEISS

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Citations

Jan 1, 1985·Physiology & Behavior·K E AsinB Tabakoff
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·S J Cooper, L B Estall
Aug 27, 2011·Infectious Diseases in Obstetrics and Gynecology·Jason D BellDorothy L Patton

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