PMID: 3768354Oct 23, 1986Paper

The effect of benzyl alcohol and cholesterol on the acyl chain order and alkane solubility of bimolecular phosphatidylcholine membranes

Biochimica Et Biophysica Acta
H G Coster, D R Laver

Abstract

An investigation was made of the effects of cholesterol and benzyl alcohol on the partitioning of n-alkanes between lipid bilayer membranes and bulk lipid/alkane solutions (in the torus). Bilayers were formed from solutions containing alkanes of different chain lengths, together with phosphatidylcholine and cholesterol in varying proportions. The partitioning of the alkanes was determined from measurements of the very low frequency (1 Hz) capacitance of the membranes. Perturbation of the internal membrane structure by the inclusion of cholesterol and benzyl alcohol produced very significant changes in the n-alkane partition coefficient, cholesterol causing a decrease and benzyl alcohol an increase in the alkane partitioning into the bilayer. A correlation exists between the effects of these compounds on the alkane partitioning and their effect on the segmental chain order of the acyl chains in the bilayer and this correlation is consistent with a statistical-mechanical model of the lipid/alkane bilayers in the liquid crystalline state. The perturbation by cholesterol and benzyl alcohol of the internal structure of membranes bears on the conflicting reports of the effects of these substances on artificial lipid bilayers and coul...Continue Reading

Citations

Nov 9, 2002·International Journal of Food Microbiology·Mario AguedoJean-Marc Belin
Dec 4, 2003·Bioelectrochemistry·Lyn D Oliver, Hans G L Coster
Oct 15, 2005·Biophysical Chemistry·Thomas H AagaardPeter Westh
Feb 12, 1998·Biochimica Et Biophysica Acta·C KarolisK D Barrow
Jan 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Heidi D AndersenPeter Westh
Mar 4, 2010·Biophysical Journal·Rocio K Finol-UrdanetaCatherine E Morris
Nov 3, 2016·The Journal of Membrane Biology·Hadeel AlobeedallahHans Coster
Aug 5, 2006·Biophysical Chemistry·Ulf R PedersenPeter Westh
Dec 1, 2017·The Journal of Membrane Biology·Hadeel AlobeedallahHans Coster
Jun 12, 2008·Physiological Measurement·T C ChilcottH G L Coster

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