The effect of berberis vulgaris extract on transaminase activities in non-alcoholic Fatty liver disease

Hepatitis Monthly
Raziye Iloon KashkooliMehdi Birjandi

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disorder in western countries and an important cause of liver cirrhosis, as well as liver failure. Up to now, 20‒40% of the individuals suffer from this disorder and its prevalence is estimated around 5‒30% in Asia. The NAFLD is one of the most prevalent causes for increases in liver enzymes and has a close relationship with obesity, dyslipidemia, hypertension, and type II diabetes. However, no definite treatment has been identified for it yet. The present study aimed to investigate the effect of berberis vulgaris extract in inducing changes in liver enzymes levels. The present clinical trial was conducted on 80 patients, including 32 males (40%) and 48 females (60%), who were randomly assigned into two groups of case and control. All the patients had ultrasound evidence of lipid accumulation in the liver and increases in liver enzymes. The case group received two capsules (750 mg) containing berberis vulgaris extract every day for 3 months, while the control group was treated with placebo. The weight, liver transaminases levels and lipid profiles of the two groups were assessed before, during, and after the study. In the case group, the mean serum levels of ...Continue Reading

References

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Citations

Jun 5, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Seyed Ali Javad-MousaviMehdi Goudarzi
Nov 5, 2016·Phytotherapy Research : PTR·Mohsen Imenshahidi, Hossein Hosseinzadeh
Jan 15, 2019·Phytotherapy Research : PTR·Mohsen Imenshahidi, Hossein Hosseinzadeh
Oct 13, 2020·Archives of Physiology and Biochemistry·Babak RoshanravanSaeed Samarghandian
Jun 1, 2021·Phytotherapy Research : PTR·Sapana BansodChandraiah Godugu
Mar 10, 2020·Complementary Therapies in Medicine·Mohammad Reza AminiSakineh Shab-Bidar

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