PMID: 6113828Mar 1, 1981Paper

The effect of beta-adrenergic blockade on infarct size following experimental coronary occlusion

Basic Research in Cardiology
K GenthW Schaper

Abstract

The effect of Pindolol on myocardial infarct size was studied in 10 open chest dogs. In each animal a sequential occlusion and reperfusion of 2 medium-sized branches of the left coronary artery was performed in the same heart. After occlusion and reperfusion of the control artery the initial dose of Pindolol (0.25 mg/kg body weight) was administered. Thereafter the test artery was occluded, followed by a maintenance dose of Pindolol (0.3 mg/kg body weight). The drug caused a significant decrease in LVP and LV-dp/dt but no change in heart rate. MVO2 also decreased significantly. Regional myocardial blood flow was measured with the tracer microsphere method. Collateral flow in the perfusion area of the control artery was 11.2 +/- 5.9% and in the area of the test artery 10.0 +/- 4.4% of normal. No change in the endo/epi ratio as a result of treatment was observed. The area of infarction (p-nitroblue tetrazolium-reaction) was divided by the area of perfusion (angiography). Infarct size, expressed as the percentage of the perfusion area, was 48.2 +/- 22.2% in the region of the control artery and 43.0 +/- 23.9% in the region of the test artery. The difference was statistically not significant.

References

Jan 1, 1979·Basic Research in Cardiology·W SchaperW Hort
Feb 1, 1979·The Journal of Pathology·M J DaviesW B Robertson
Nov 1, 1977·British Heart Journal·L WilhelmsenH Wedel
Jan 1, 1973·Basic Research in Cardiology·W SchaperL Gijpen
Apr 1, 1971·The American Journal of Cardiology·E Braunwald
Apr 1, 1970·Cardiovascular Research·B Pitt, P Craven
Jul 1, 1980·Basic Research in Cardiology·M HofmannW Schaper
Nov 29, 1980·British Medical Journal·L H Opie, D A White
Jan 13, 1962·British Medical Journal·E SOWTON

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Citations

Sep 1, 1983·The American Journal of Cardiology·C S RobertsR A Kloner
Jul 1, 1991·The Journal of Surgical Research·W E BrownJ D Mannion
Jul 1, 1990·Basic Research in Cardiology·W FlamengJ Vanhaecke
May 1, 1982·Basic Research in Cardiology·P A MartoranaR E Nitz
Jun 15, 2021·Chonnam Medical Journal·Hyun Kuk KimJoo-Young Na

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