The effect of betaine treatment on triglyceride levels and oxidative stress in the liver of ethanol-treated guinea pigs

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
Jale BalkanMüjdat Uysal

Abstract

We investigated the effect of betaine supplementation on ethanol induced steatosis and alterations in prooxidant and antioxidant status in the liver of guinea pigs. Animals were fed with normal chow or betaine containing chow (2% w/w) for 30 days. Ethanol (3 g/kg, i.p.) was given for the last 10 days. We found that ethanol treatment caused significant increases in plasma transaminase activities, hepatic triglyceride and lipid peroxide levels. Significant decreases in glutathione (GSH), alpha-tocopherol and total ascorbic acid (AA) levels were also observed, but hepatic superoxide dismutase, glutathione peroxidase and glutathione transferase activities remained unchanged as compared with those in controls. Betaine treatment together with ethanol in guinea pigs is found to decrease hepatic triglyceride, lipid peroxide levels and serum transaminase activities and to increase GSH levels. No changes in alpha-tocopherol and total AA levels and antioxidant enzyme activities were observed with betaine treatment in alcohol treated guinea pigs. In addition, histopathological assessment of guinea pigs showed that betaine reduced the alcoholic fat accumulation in the liver. Based on these data, betaine treatment has a restoring effect on t...Continue Reading

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Citations

May 1, 2013·Critical Reviews in Food Science and Nutrition·Anthony Fardet, Jean-Michel Chardigny
Feb 18, 2012·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Esra Betül KalazNecla Koçak-Toker
May 15, 2007·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Seda YalçinkayaMüjdat Uysal
Jun 24, 2006·Alcoholism, Clinical and Experimental Research·Jesus A VillanuevaCharles H Halsted
Oct 29, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Ni ChengWei Cao
Aug 23, 2008·Chemico-biological Interactions·Tao ZengKe-Qin Xie
Jun 18, 2016·Environmental Toxicology and Pharmacology·İlknur BingülMüjdat Uysal
Aug 6, 2016·International Immunopharmacology·İlknur BingülMüjdat Uysal
Sep 30, 2016·Journal of Agricultural and Food Chemistry·Mengmeng ZhangHui Wu
Aug 13, 2020·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Milena VeskovićTatjana Radosavljević
Mar 17, 2009·Molecular Biology Reports·B GanesanR AnbinEzhilan
Dec 14, 2011·Journal of Enzyme Inhibition and Medicinal Chemistry·Jae-Young ChaYoung-Su Cho
Sep 2, 2011·The Journal of Nutrition·Rafael DeminiceJohn T Brosnan

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