The effect of bifenthrin on the dopaminergic pathway in juvenile rainbow trout (Oncorhynchus mykiss)

Aquatic Toxicology
Jordan Crago, D Schlenk

Abstract

Bifenthrin is a type I pyrethroid pesticide, which has been shown to increase plasma estrogen concentrations in several fish models. The mechanism of action by which bifenthrin alters 17β-estradiol (E2) is unclear. E2 biosynthesis is regulated through pituitary follicle stimulating hormone, which is directly controlled by hypothalamic gonadotropin releasing hormone (GnRH2). Since dopaminergic signaling significantly influences GnRH2 release in fish, the goal of the study was to determine the effect of a 96 h and 2 weeks exposure to bifenthrin on dopaminergic signaling in juvenile rainbow trout (Oncorhynchus mykiss) (RT). Our results indicated that a decrease in dopamine receptor 2A (DR2A) expression was associated with a trend toward an increase in plasma E2 following exposure at 96 h and 2 weeks, and a significant increase in the relative expression of vitellogenin mRNA at 2 weeks. DR2A mRNA expression decreased 426-fold at 96 h and 269-fold at 2 weeks in the brains of 1.5 ppb (3.55 pM) bifenthrin treated RT. There was an increase in tyrosine hydroxylase transcript levels at 96 h, which is indicative of dopamine production in the brains of the 1.5 ppb (3.55 pM) bifenthrin treated RT. A significant increase in the relative expr...Continue Reading

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Citations

Jan 12, 2016·General and Comparative Endocrinology·Jordan CragoDaniel Schlenk
Jun 15, 2016·Chemosphere·William H MimbsJason B Belden
Jul 28, 2016·Environmental Science & Technology·Susanne M BranderDaniel Schlenk
Aug 24, 2016·Environmental Monitoring and Assessment·Kaiwei ShiFengmao Liu
Aug 18, 2017·Environmental Toxicology and Chemistry·Luísa Becker BertottoDaniel Schlenk
Jan 27, 2019·Environmental Toxicology and Chemistry·Marissa GirouxDaniel Schlenk
Sep 10, 2020·Environmental Science & Technology·Jason MagnusonDaniel Schlenk

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