The effect of bilateral fetal adrenalectomy on fluid balance in the ovine fetus

The Journal of Physiology
C A Benson, E M Wintour

Abstract

1. Bilaterally adrenalectomized adult sheep, taken off replacement therapy, exhibit decreased plasma sodium, and increased plasma potassium, urinary sodium excretion and urinary sodium:potassium ratio. The hypothesis tested was that these effects would not be seen in adrenalectomized ovine fetuses, due to the mother being the major regulator of fetal fluid balance. 2. The fetuses of seven Merino ewes were bilaterally adrenalectomized at 120 +/- 0.3 days of gestation (term is 150 days) and a bladder cannula inserted. Urine flow and composition were measured six times between 125 and 142 days of gestation, and compared with results in seven control fetuses at the same gestational ages. At between 142 and 145 days of gestation, blood samples were taken from the ewe and fetus, they were killed and the volume and composition of amniotic and allantoic fluids measured. 3. Adrenalectomized fetuses had significantly lower (P < 0.05) plasma aldosterone concentration than that observed in intact fetuses (adrenalectomized, 92 +/- 16 pmol l-1; intact, 224 +/- 46 pmol l-1; P < 0.001). Plasma cortisol level was also lower (adrenalectomized, 8.6 +/- 1.4 nmol l-1; intact, 110.3 +/- 24.8 nmol l-1). Maternal plasma steroids were similar in both g...Continue Reading

Citations

Feb 19, 2002·Kidney International·Vicky HantzisMiodrag Dodic
Aug 3, 2001·American Journal of Obstetrics and Gynecology·J P NewnhamA Jobe
Jun 19, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J GuanZ Xu
Feb 8, 2005·Journal of the Society for Gynecologic Investigation·Maureen Keller-WoodDaying Zhang
Nov 1, 2003·Cloning and Stem Cells·Gabriela Gebrin Cezar
Dec 14, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karen M MoritzMiodrag Dodic
Feb 18, 2011·Canadian Journal of Physiology and Pharmacology·Sonnet S JonkerJeffrey L Segar
Jun 1, 1997·Equine Veterinary Journal. Supplement·E M Wintour, K M Moritz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.