PMID: 2511346Sep 1, 1989Paper

The effect of bile on the gastric mucosal barrier in the presence and after blockade of normal gastric acidity

JPMA. the Journal of the Pakistan Medical Association
N KostakogluM Tuncyurek

Abstract

Induced physiologic changes in the gastric mucosa was investigated both in the presence of normal gastric acidity and after parietal cell vagotomy (PCV), in dogs. Cholecystogastrostomy and common bile duct ligation was performed in eleven and PCV was added to this procedure in five dogs. During histopathological examination, 70 days after the procedure, both groups proved to have superficial gastritis. The most prominent changes occurred at the anastomotic site and at the gastric antrum. Bile had broken down the gastric mucosal barrier and the Na+ flux roughly paralleled the H+ back diffusion. Potassium had taken part in the bi-directional movement of ions in the gastric mucosa, as well as the sodium flux, and in the late phase it accompanied the action of sodium ions. The destruction of the K+-H+ pump, possibly located in the plasma membrane, may be the responsible mechanism of this flux.

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Related Papers

Scandinavian Journal of Gastroenterology. Supplement
U C ScheurerC F Code
Comparative Biochemistry and Physiology. A, Comparative Physiology
M Vernay
Surgery, Gynecology & Obstetrics
K D Lillemoe, J W Harmon
European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
W E Thomas
© 2022 Meta ULC. All rights reserved