The Effect of Blood Lipids on the Left Ventricle: A Mendelian Randomization Study.

Journal of the American College of Cardiology
Nay AungSteffen E Petersen

Abstract

Cholesterol and triglycerides are among the most well-known risk factors for cardiovascular disease. This study investigated whether higher low-density lipoprotein (LDL) cholesterol and triglyceride levels and lower high-density lipoprotein cholesterol level are causal risk factors for changes in prognostically important left ventricular (LV) parameters. One-sample Mendelian randomization (MR) of 17,311 European individuals from the UK Biobank with paired lipid and cardiovascular magnetic resonance data was performed. Two-sample MR was performed by using summary-level data from the Global Lipid Genetics Consortium (n = 188,577) and UK Biobank Cardiovascular Magnetic Resonance substudy (n = 16,923) for sensitivity analyses. In 1-sample MR analysis, higher LDL cholesterol was causally associated with higher LV end-diastolic volume (β = 1.85 ml; 95% confidence interval [CI]: 0.59 to 3.14 ml; p = 0.004) and higher LV mass (β = 0.81 g; 95% CI: 0.11 to 1.51 g; p = 0.023) and triglycerides with higher LV mass (β = 1.37 g; 95% CI: 0.45 to 2.3 g; p = 0.004). High-density lipoprotein cholesterol had no significant association with any LV parameter. Similar results were obtained by using 2-sample MR. Observational analyses were frequently...Continue Reading

Citations

Apr 10, 2021·Journal of the American College of Cardiology·Panagiota PietriChristodoulos Stefanadis
Aug 21, 2021·Pharmacogenomics and Personalized Medicine·Shujuan ChuYue Qian
Sep 3, 2021·Current Opinion in Lipidology·Viviane Z Rocha, Raul D Santos
Nov 21, 2020·Journal of the American College of Cardiology·Robert Roberts

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