The effect of BMI on clinicopathologic and functional outcomes after open radical prostatectomy

Urologic Oncology
Philipp MandelDerya Tilki

Abstract

To analyze the effect of body mass index (BMI) on pathologic and functional outcomes after open radical retropubic prostatectomy. We retrospectively analyzed 2,471 patients who underwent RP. Clinicopathologic and patient characteristics were compared with respect to patients' BMI (normal weight: BMI < 25 kg/m(2) [n = 795], overweight: BMI ≥ 25 kg/m(2) and < 30 kg/m(2) [n = 1305], and obese: BMI ≥ 30 kg/m(2) [n = 371]). Multivariable logistic and linear regression models were used to quantify the effect of BMI on pathologic and functional outcomes. Compared with normal weight patients, overweight and obese patients demonstrated higher pathologic Gleason grade and higher pathologic T stage, without any difference in preoperative prostate-specific antigen levels. Overweight and obese men were less likely to have a negative surgical margin (odds ratio (OR) 0.74 [confidence interval (CI) 0.65-0.84, P<0.001] for overweight men and OR 0.66 [CI 0.49-0.89, P<0.01] for obese men) and had a lower rate of postoperative erectile function (OR 0.60 [CI 0.48-0.76, P<0.001] for overweight patients and OR 0.34 [CI 0.27-0.44, P<0.001] for obese patients). Moreover, duration of surgery and intraoperative blood loss increased significantly with an ...Continue Reading

References

Jan 12, 2005·The Journal of Urology·James A BrownDouglas M Dahl
Mar 1, 2006·Prostate Cancer and Prostatic Diseases·T L MulhollandK M Peters
Aug 2, 2006·BJU International·Christopher G EdenDaniel A Moon
May 19, 2007·The Journal of Urology·Ian ThompsonUNKNOWN AUA Prostate Cancer Clinical Guideline Update Panel
Dec 11, 2007·International Journal of Andrology·Boris W V SchoutenJ L H Ruud Bosch
Jul 11, 2008·Journal of Endourology·Stephen A BoorjianMatthew T Gettman
May 15, 2009·Urologia Internationalis·Joep G H van RoermundJ Alfred Witjes
Jun 16, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Uri LindnerJohn Trachtenberg
Jul 24, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Joep G H van Roermund
Sep 10, 2011·JSLS : Journal of the Society of Laparoendoscopic Surgeons·Ekong E Uffort, James C Jensen

❮ Previous
Next ❯

Citations

Oct 22, 2015·Journal of Surgical Oncology·Lawrence E HarrisonRobert Korst
Mar 31, 2015·Urologic Oncology·Philipp MandelDerya Tilki
Jun 21, 2017·Current Opinion in Urology·Marco BandiniAlberto Briganti
Nov 12, 2019·Expert Review of Cardiovascular Therapy·Alessandro AndreisGaetano Maria de Ferrari
Nov 12, 2019·Frontiers in Surgery·Lena TheissenPhilipp Mandel
Oct 30, 2021·International Journal of Clinical Oncology·Sung Jin KimJong Yeon Park

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.