The effect of body mass index on spinal anaesthesia for total knee replacement arthroplasty: a dose-response study

Anaesthesia and Intensive Care
W H KimG S Kim

Abstract

The aim of this study was to compare the duration of spinal anaesthesia in obese and non-obese subjects. We also quantified the effect of body mass index (BMI) on spinal anaesthesia by comparing the median effective dose (ED50) of intrathecal hyperbaric bupivacaine required in the two cohorts. One hundred and eight patients undergoing elective total knee replacement arthroplasty under combined spinal-epidural anaesthesia were enrolled as a non-obese group (BMI <27.5 kg/m(2)) or obese (O) group (BMI ≥ 27.5 kg/m(2)). Each group was further subdivided by bupivacaine doses of 6, 7, 8, 9, 10 or 11 mg, respectively. Anaesthesia was deemed successful if a bilateral T12 sensory block occurred within 15 minutes of intrathecal drug administration and epidural supplementation was not required. The ED50 for successful anaesthesia and that for successful block of tourniquet pain were determined separately by probit regression analysis. Although the analgesic duration was prolonged with higher doses of bupivacaine in group O, the ED50 for successful anaesthesia did not differ between groups. However, the incidence of tourniquet pain was lower in group O and the ED50 for block of tourniquet pain was less in group O. This study suggests that b...Continue Reading

References

Jun 1, 1986·British Journal of Anaesthesia·W J McCulloch, D G Littlewood
Mar 1, 1986·British Journal of Anaesthesia·M R LoganJ A Wildsmith
Jul 15, 1968·American Journal of Obstetrics and Gynecology·D L BarclayE W Nelson
Mar 1, 1984·British Journal of Anaesthesia·M PitkänenP H Rosenberg
Nov 9, 2000·Anaesthesia·C R BroadbentR Russell
Jun 1, 1964·British Journal of Anaesthesia·P R BROMAGER T PETTIGREW
Jun 29, 2004·British Journal of Anaesthesia·G Hocking, J A W Wildsmith
Sep 1, 2005·Anesthesiology·Brendan CarvalhoEdward T Riley
May 18, 2006·Environmental Toxicology and Chemistry·Matthew W WheelerA John Bailer

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Citations

Jun 2, 2018·Clinical Drug Investigation·Zahid HussainSyed Tabish Razi Zaidi
Sep 25, 2019·Journal of Anesthesia·Sun-Kyung ParkWon Ho Kim
May 14, 2021·Expert Review of Clinical Pharmacology·Xiaojun ChenJin Yu

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