The Effect of Body Position on Physiological Factors that Contribute to Obstructive Sleep Apnea

Sleep
Simon A JoostenGarun S Hamilton

Abstract

Obstructive sleep apnea (OSA) resolves in lateral sleep in 20% of patients. However, the effect of lateral positioning on factors contributing to OSA has not been studied. We aimed to measure the effect of lateral positioning on the key pathophysiological contributors to OSA including lung volume, passive airway anatomy/collapsibility, the ability of the airway to stiffen and dilate, ventilatory control instability (loop gain), and arousal threshold. Non-randomized single arm observational study. Sleep laboratory. 20 (15M, 5F) continuous positive airway pressure (CPAP)-treated severe OSA patients. Supine vs. lateral position. CPAP dial-downs performed during sleep to measure: (i) Veupnea: asleep ventilatory requirement, (ii) passive V0: ventilation off CPAP when airway dilator muscles are quiescent, (iii) Varousal: ventilation at which respiratory arousals occur, (iv) active V0: ventilation off CPAP when airway dilator muscles are activated during sleep, (v) loop gain: the ratio of the ventilatory drive response to a disturbance in ventilation, (vi) arousal threshold: level of ventilatory drive which leads to arousal, (vii) upper airway gain (UAG): ability of airway muscles to restore ventilation in response to increases in ven...Continue Reading

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Citations

Oct 5, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Bradley A EdwardsAmy S Jordan
Jan 13, 2018·American Journal of Respiratory and Critical Care Medicine·Scott A SandsAndrew Wellman
Jan 11, 2018·Sleep & Breathing = Schlaf & Atmung·Marcello BosiVenerino Poletti
Oct 27, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Maria R BonsignoreJosep M Montserrat
May 25, 2016·Sleep & Breathing = Schlaf & Atmung·Özgür Bilgin TopçuoğluKayıhan Uluç
Jul 6, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Marcello BosiGiulio Alessandri-Bonetti
Nov 16, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Marcello BosiVenerino Poletti
Jul 22, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Simon A JoostenBradley A Edwards
Dec 1, 2017·American Journal of Respiratory and Critical Care Medicine·Jeremy E OrrAtul Malhotra
Aug 15, 2019·Sleep & Breathing = Schlaf & Atmung·Paula Martínez Ruiz de ApodacaJosé Dalmau Galofre
Nov 20, 2018·Frontiers in Neurology·Naomi Deacon-Diaz, Atul Malhotra
Jan 30, 2019·Sleep & Breathing = Schlaf & Atmung·Hideaki NakayamaYuichi Inoue
Jul 6, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Eugenio De CorsoEmanuele Scarano
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Oct 24, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Simon A JoostenBradley A Edwards
Nov 17, 2020·Chest·Simon A JoostenBradley A Edwards
Nov 16, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Stuart G MacKayNicolette R Holt
Dec 12, 2020·Nature and Science of Sleep·Himanshu GargSubash S Heraganahally
Jan 12, 2021·Sleep & Breathing = Schlaf & Atmung·M J L RaveslootN de Vries
Sep 25, 2020·American Journal of Respiratory and Critical Care Medicine·Sara Op de BeeckUNKNOWN STAR Trial Investigators
Jun 23, 2021·American Journal of Respiratory and Critical Care Medicine·Andrey V ZinchukScott A Sands
Nov 6, 2021·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Gino Seravalle, Guido Grassi

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