Apr 1, 1976

The effect of Bordetella pertussis on the antibody response in mice to type III pneumococcal polysaccharide

The Journal of Immunology : Official Journal of the American Association of Immunologists
A S Kong, S I Morse

Abstract

The effect of an i.p. injection of Bordetella pertussis on the primary humoral immune response in mice to the thymus-independent antigen SIII has been studied. Suppression of the antibody response occurred when pertussis cells were injected at the same time as an optimal immunizing dose of SIII. In contrast, the antibody response to high doses of SIII was enhanced by B. pertussis. When SIII alone was injected, only 19S antibody was detected. However, when B. pertussis was administered with either optimal or high doses of SIII, 7S as well as 19S antibody against SIII was produced.

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Mentioned in this Paper

Centrifugation, Density Gradient
Pertussis
TCEB1 gene
Ir1
Humoral Immunity
TCEB3 gene
Pertussis Vaccine
Polysaccharides, Bacterial
Antibody Formation
Antigens, T-Independent

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