The effect of botulinum toxin on ureteral inflammation.

World Journal of Urology
Kevin KrughoffDavid R Chavez

Abstract

The impact of onabotulinum toxin type A (BoNT-A) on bladder afferent nerve pathways and chemosensory functions is an active area of investigation. There may be a role for BoNT-A in disorders of the ureter; however, no histologic studies have assessed the effects of BoNT-A on ureteral tissue. Our objective was to develop an animal model of ureteral inflammation and determine the impact of ureteral BoNT-A instillation on known mechanisms of inflammation. The safety and feasibility of a novel animal model of ureteral inflammation was assessed. Through open cystotomy, the effect of ureteral BoNT-A instillation on inflammation was determined through H&E, masson's trichrome, Ki-67 stain, and prostaglandin E (PGE) synthase expression, a known marker of pain and inflammation in ureteral tissue. Urothelial microstructure was assessed using electron microscopy and standard histologic techniques. All experiments were carried to completion, and no systemic signs of botulinum toxicity were seen. BoNT-A exposure was associated with a decrease in PGE synthase expression in a dose-dependent fashion. BoNT-A exposure was not found to impact collagen deposition or cell proliferation. Disruption of tight junctions between urothelial cells was obse...Continue Reading

References

Nov 16, 2002·Prostaglandins & Other Lipid Mediators·Makoto MurakamiIchiro Kudo
Jul 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Catherine E TrebinoLaurent P Audoly
May 14, 2004·The Journal of Biological Chemistry·Daisuke KameiIchiro Kudo
Mar 31, 2005·Journal of Endourology·Patrick S LowryStephen Y Nakada
Dec 7, 2005·The Journal of Cell Biology·Feng-Xia LiangTung-Tien Sun
Mar 7, 2008·American Journal of Physiology. Renal Physiology·Prerna RastogiJane McHowat
Jun 22, 2010·International Urology and Nephrology·Jan Krhut, Peter Zvara
Dec 21, 2010·Urology·Abdol-Mohammad KajbafzadehMasoud Sotoudeh
Jan 19, 2016·Urology·Christopher J Chermansky, Michael B Chancellor
Mar 2, 2016·Nature Reviews. Urology·Liana MerrillMargaret A Vizzard
Aug 5, 2017·American Journal of Physiology. Renal Physiology·James A HokansonWarren M Grill
Nov 14, 2017·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Shuntaro Hara
Apr 22, 2020·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Zi-Ao HuangDirk Lange

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