The effect of brain atrophy on outcome after a large cerebral infarction

Journal of Neurology, Neurosurgery, and Psychiatry
Sang Hyung LeeYoung Seob Chung

Abstract

We retrospectively evaluated the effect of brain atrophy on the outcome of patients after a large cerebral infarct. Between June 2003 and Oct 2008, 134 of 2975 patients with stroke were diagnosed as having a large cerebral infarct. The mean age of the patients was 70 (21-95) y. The mean infarct volume was 223.6±95.2 cm(3) (46.0-491.0). The inter-caudate distance (ICD) was calculated as an indicator of brain atrophy by measuring the hemi-ICD of the intact side and then multiplying by two to account for brain swelling at the infarct site. The mean ICD was 18.0±4.8 mm (9.6-37.6). Forty-nine (36.6%) patients experienced a malignant clinical outcome (MCO) during management in the hospital. Thirty-one (23.1%) patients had a favourable functional outcome (FO) (modified Rankin scale (mRS) ≤3) and 49 (36.6%) had an acceptable functional outcome (AO) (mRS≤4) at 6 months after stroke onset. In the multivariate analysis, brain atrophy (ICD≥20 mm) had a significant and independent protective effect on MCO (p=0.003; OR=0.137; 95% CI 0.037 to 0.503). With respect to FO, the age and infarct volume reached statistical significance (p<0.001, OR=0.844, 95% CI 0.781 to 0.913; p=0.006, OR=0.987, 95% CI 0.977 to 0.996, respectively). Brain atrophy (...Continue Reading

Citations

Aug 25, 2015·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Nicholas M DesyRobert J Spinner
Oct 15, 2013·Geriatrics & Gerontology International·Christian DehlendorffTom Skyhøj Olsen
Apr 18, 2015·Journal of Neurosurgery·Young-Hoon KimChang Wan Oh
May 29, 2015·Current Atherosclerosis Reports·Carolina B Maciel, Kevin N Sheth
Aug 5, 2017·Stroke; a Journal of Cerebral Circulation·Magnus ThorénNiaz Ahmed
Feb 16, 2013·Stroke; a Journal of Cerebral Circulation·Christian HerwehMartin Bendszus
Dec 21, 2018·Stroke; a Journal of Cerebral Circulation·Simiao WuMing Liu
Aug 27, 2019·Stroke; a Journal of Cerebral Circulation·Simone M Uniken VenemaJonathan Rosand
Nov 14, 2019·Korean Journal of Neurotrauma·Alexandrina S NikovaTheodossios Birbilis
Sep 21, 2019·Stroke; a Journal of Cerebral Circulation·Pongpat VorasayanW Taylor Kimberly
Nov 25, 2018·Journal of Neurology·Hannah FuhrerUNKNOWN IGNITE-study group
May 29, 2019·Stroke; a Journal of Cerebral Circulation·Shoujiang YouJohn Chalmers
Feb 18, 2015·Current Opinion in Critical Care·Alicia M ZhaMichel T Torbey
May 15, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Sebastian MönchBenjamin Friedrich

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.