PMID: 6112173Jan 1, 1981Paper

The effect of bromazepam on psychomotor activity and subjective mood

The Journal of International Medical Research
V HobiH Riggenbach

Abstract

The effects of short-term (acute) doses of bromazepam were studied in a double-blind trial with the aid of three dosage groups comprising a total of fifty-five healthy male medical students (who received placebo, and 1.5 mg or 3.0 mg bromazepam, respectively). Subjective well-being was recorded through self-ratings by the volunteers, and the variables of psychomotor function by standard testing instruments. In terms of subjective well-being, fatigue and decreased performance (statistically confirmed throughout) were reported by the probands in all three dosage groups after they were administered either the drug or placebo. None of the dose-effect relationships were statistically significant, although this trend was more pronounced, purely in quantitative terms, in the group that received 3 mg bromazepam than in either the placebo or the 1.5 mg bromazepam group. In the reaction time and in critical flicker-frequency (CFF) testing, the trend mentioned above was confirmed. In the attentiveness and memory span test, learning effects were statistically confirmed in equally uniform fashion. The action of the substance was again not statistically significant. It may be concluded from this that subjective, and also in part objective, f...Continue Reading

References

Jan 1, 1973·The Journal of Pharmacy and Pharmacology·R W BellP Turner
Jul 1, 1966·Journal of Pharmaceutical Sciences·J A De SilvaG Bader
Feb 14, 1969·Deutsche medizinische Wochenschrift·P KielholzP Schmid
Dec 1, 1974·British Journal of Clinical Pharmacology·T Silverstone

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Citations

Aug 1, 1987·British Journal of Addiction·S D Ferrara
Nov 15, 2014·Clinical EEG and Neuroscience·Mariana GongoraPedro Ribeiro
Jan 1, 1982·The Journal of International Medical Research·V HobiH Riggenbach
Jan 1, 1982·The Journal of International Medical Research·V Hobi
Jan 22, 2003·British Journal of Clinical Pharmacology·S J de VisserJ M A van Gerven

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