PMID: 7035013Nov 1, 1981Paper

The effect of bromocriptine on insulin secretion and glucose tolerance in patients with acromegaly

Clinical Endocrinology
C M FeekJ D Baird

Abstract

The oral administration of bromocriptine 5 mg 6-hourly to twelve patients with acromegaly for a mean period of 12 (range 3-27) months significantly reduced whole blood glucose, plasma insulin and plasma growth hormone (GH) concentrations during a 50 g oral glucose tolerance test (OGTT). After this period of treatment, bromocriptine was withdrawn for 48 h resulting in a significant rise in whole blood glucose, plasma insulin and plasma GH concentrations during a repeat OGTT. It is concluded that bromocriptine therapy improves glucose tolerance in acromegaly by suppressing GH secretion and consequently GH-mediated antagonism of insulin.

References

Jun 1, 1977·Acta Endocrinologica·L BelforteF Silvestrini
Apr 1, 1978·Acta Endocrinologica·P G EskildsenJ Nerup
Jan 1, 1979·The Journal of Clinical Endocrinology and Metabolism·M MuggeoP Gorden
Apr 2, 1977·British Medical Journal·J A WassG M Besser
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Oct 1, 1980·Clinical Endocrinology·D G JohnstonR Hall

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Citations

Apr 13, 1987·Life Sciences·E S el-DensharyA R Abu-Jayyab
Jul 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·R A JamesP Kendall-Taylor
Jun 1, 1992·The Journal of Clinical Investigation·P D ZenobiE R Froesch
Dec 1, 1992·The Journal of Clinical Investigation·P D ZenobiE R Froesch
Feb 26, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M G BaroniUNKNOWN Italian Endocrinological Society (SIE)
Jan 10, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Felicitas Lopez VicchiDamasia Becu-Villalobos
Jul 8, 2020·Expert Opinion on Pharmacotherapy·Sylvère Störmann, Jochen Schopohl
Apr 1, 1987·Medicinal Research Reviews·H RoehrichM S Gold

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