The effect of bromocriptine treatment on sexual functioning and depressive symptoms in women with mild hyperprolactinemia

Pharmacological Reports : PR
R KrysiakB Okopień

Abstract

Elevated prolactin levels are associated with sexual dysfunction in women. No previous study has investigated the effect of dopamine agonists on sexual functioning in women. The study enrolled 30 young women with mild hyperprolactinemia (serum prolactin levels in the range between 25 and 50ng/mL), 15 of whom were later treated with bromocriptine (5-10mg daily), as well as 14 age- and weight-matched healthy women. All women completed a questionnaire evaluating female sexual function (Female Sexual Function Index - FSFI) and a questionnaire evaluating the presence and severity of depressive symptoms (Beck Depression Inventory Second Edition - BDI-II). Women with mild hyperprolactinemia had a lower total FSFI score, lower scores in all domains of sexual functioning (desire, arousal, lubrication, and dyspareunia), as well as a lower total BDI-II score than control women. Bromocriptine increased the FSFI score and tended to reduce BDI-II score. Moreover, the drug normalized desire, arousal, lubrication and dyspareunia, as well as improved orgasm and sexual satisfaction and this action correlated with changes in prolactin levels and an improvement in insulin sensitivity. No changes in sexual functioning and depressive symptoms were o...Continue Reading

References

Nov 5, 1977·Lancet·B AmbrosiG Faglia
Dec 1, 1996·Journal of Personality Assessment·A T BeckW Ranieri
Sep 2, 2000·Journal of Neuroimmunology·L MateraG Palestro
Feb 12, 2002·Neuroscience and Biobehavioral Reviews·Tillmann H C KrügerMichael S Exton
Dec 6, 2003·The Journal of Endocrinology·T H C KrügerM Schedlowski
Feb 13, 2004·International Journal of Impotence Research·G CoronaM Maggi
Apr 22, 2005·Journal of Sex & Marital Therapy·Markus WiegelRaymond Rosen
Oct 12, 2005·The Journal of Urology·Pinar KadiogluAtes Kadioglu
Nov 29, 2005·Endocrine·Gabriella IvánMiklós I Góth
Sep 25, 2007·Best Practice & Research. Clinical Obstetrics & Gynaecology·V K B Prabhakar, J R E Davis
Feb 13, 2009·The Journal of Sexual Medicine·Giovanni CoronaMario Maggi
Jun 3, 2009·Clinical Endocrinology·Naoki HattoriYasuhiko Saiki
Feb 16, 2012·Human Reproduction·Tillmann H C KrugerMarcel Egli
May 4, 2012·Current Topics in Behavioral Neurosciences·Patricia A ZunszainCarmine M Pariante
Jan 25, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiao-Bing JiangHai-Jun Wang
Oct 8, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·Michael Fahie-Wilson, Thomas P Smith

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