The effect of Brucella abortus on hydrogen peroxide and nitric oxide production by bovine polymorphonuclear cells

Veterinary Research Communications
L Iyankan, D K Singh

Abstract

The effect of Brucella on the generation of microbicidal reactive oxygen and nitrogen metabolites by bovine peripheral polymorphonuclear cells (PMNs) was investigated. The PMNs were recovered from the peripheral blood of control calves and experimental calves previously vaccinated against brucellosis. Significantly larger quantities of NO and H2O2 were generated by PMNs from control and experimental calves following activation by heat-killed whole cells or outer membrane protein of Brucella abortus than by non-activated cells (p<0.05-0.01). In contrast, generation of H2O2 and NO decreased when PMNs were exposed to the lipopolysaccharide of Brucella. However, the generation of H2O2 and NO by activated PMNs from the control and experimental calves did not differ significantly.

Citations

Nov 2, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M RefikY Ersoy
Mar 1, 2012·FEMS Microbiology Reviews·Kristine von BargenSuzana P Salcedo
Oct 16, 2020·Microbiology and Molecular Biology Reviews : MMBR·Edgardo Moreno, Elías Barquero-Calvo

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