The effect of budesonide/formoterol pressurized metered-dose inhaler on predefined criteria for worsening asthma in four different patient populations with asthma.

Drugs in R&D
Kevin R MurphyJames Zangrilli

Abstract

Previous studies have shown disparities between Black and Hispanic patients compared with other populations in response to asthma medications. The aim of this analysis was to assess the effect of budesonide/formoterol pressurized metered-dose inhaler (BUD/FM pMDI) and BUD on predefined criteria for asthma worsening, an asthma control metric generally aligned with definitions of moderate asthma exacerbations, across four different populations. Data were from four 12-week, randomized, double-blind, US studies of BUD/FM pMDI treatment in patients aged 12 years or older with varying asthma severities and of varying races. Predefined asthma events and withdrawals due to predefined events were assessed as secondary study endpoints. Study I (NCT00651651) includes data from predominantly White patients with mild to moderate asthma who were randomized to BUD/FM pMDI 160/9 μg twice daily (bid; n = 123) or BUD pMDI 160 μg bid (n = 121). Study II (NCT00652002) includes data from predominantly White patients with moderate to severe asthma who were randomized to BUD/FM pMDI 320/9 μg bid (n = 124) or BUD pMDI 320 μg bid (n = 109). Study III (NCT00702325) included self-reported Black patients with moderate to severe asthma who were randomized ...Continue Reading

References

Jun 19, 2009·American Journal of Respiratory and Critical Care Medicine·Helen K ReddelUNKNOWN American Thoracic Society/European Respiratory Society Task Force on Asthma Control and Exacerbations
Aug 31, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·James ZangrilliChristopher D O'Brien
Dec 3, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Sheldon L SpectorChristopher D O'Brien

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Citations

Dec 5, 2012·Expert Opinion on Therapeutic Patents·Hao LiYong-Qing Wang
Aug 1, 2020·Journal of the National Medical Association·Rebecca N JeromeConsuelo H Wilkins

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