The effect of C1 spinal cord transection or bilateral adrenal vein ligation on thioridazine-induced arrhythmia and death in the cat

Journal of Clinical Pharmacology
C M LathersL J Lipka

Abstract

The phenothiazine thioridazine 1 mg/kg/min was infused intravenously into three groups of cats: (1) thioridazine alone (N = 5), (2) after bilateral adrenal ligation (N = 4), and (3) after spinal cord section at the atlanto-occipital junction (C1; N = 6). The times to arrhythmia and death with thioridazine alone were 47.8 +/- 7.8 and 72.8 +/- 5.6 minutes respectively. After bilateral adrenal ligation, arrhythmia and death occurred at 41.1 +/- 5.2 and 53.1 +/- 5.8 minutes, respectively, which showed no increase (P greater than .05) from thioridazine alone. After spinal cord section, thioridazine-induced arrhythmia and death occurred at 74.0 +/- 13.7 and 85.7 +/- 13.8 minutes, respectively, which were not increased (P greater than .05) when compared with thioridazine alone. The results of this study suggest that neither adrenomedullary catecholamines nor the central sympathetic component above C1 plays a significant role in acute thioridazine-induced arrhythmia. The action of thioridazine to induce arrhythmia in spite of transection of the spinal cord or bilateral adrenal vein ligation suggests that its cardiotoxicity is a result of a direct myocardial effect. Thioridazine depressed blood pressure without producing the sustained r...Continue Reading

References

Nov 3, 1977·The New England Journal of Medicine·R J Bladessarini
Apr 1, 1978·Toxicology and Applied Pharmacology·Y Brissette, A L Gascon
Jul 1, 1978·European Journal of Pharmacology·N A CaginB Levitt
Jan 1, 1979·International Review of Neurobiology·R J Baldessarini, D Tarsy
May 1, 1978·British Journal of Pharmacology·H BounousJ Somberg
Jun 1, 1979·The American Journal of Cardiology·M S YoonS A Jones
Jan 1, 1976·Cardiology·R A GillisD L Pearle
Dec 1, 1975·Canadian Journal of Physiology and Pharmacology·A L Gascon, J Lelorier
Feb 10, 1986·Life Sciences·C M Lathers, L J Lipka
Jun 25, 1973·JAMA : the Journal of the American Medical Association·S C Alvarez-Mena, M J Frank
Apr 1, 1968·European Journal of Pharmacology·J G Papp, L Szekeres
Jan 1, 1970·Acta Pharmacologica Et Toxicologica·K Hermansen
Jan 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·H L Weiner, W A Robinson
Apr 1, 1969·Cardiovascular Research·L CeremuzyńskiK Herbaczynska-Cedro
Jan 1, 1981·Digestive Diseases and Sciences·H H Sigman, A Gillich
Jun 1, 1981·The American Journal of Cardiology·M M KhanA A Adgey
Jan 1, 1984·General Pharmacology·C E AronsonJ F Spear
Sep 1, 1983·Journal of Molecular and Cellular Cardiology·G E THomasH Feinberg
Apr 1, 1984·Toxicology Letters·P W Hale, A Poklis
Jun 3, 1983·JAMA : the Journal of the American Medical Association·A J KemperD A Pietro

❮ Previous
Next ❯

Citations

Feb 8, 2002·Journal of Clinical Pharmacology·Claire M Lathers, Paul L Schraeder
May 2, 2009·Epilepsy & Behavior : E&B·Claire M Lathers
Dec 19, 2007·Epilepsy & Behavior : E&B·Claire M LathersMichael W Bungo
Jul 1, 1989·Journal of Clinical Pharmacology·C M LathersM W Bungo
Jan 1, 1987·Journal of Clinical Pharmacology·C M Lathers, L J Lipka
Nov 1, 1988·Journal of Clinical Pharmacology·L J LipkaJ Roberts

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.