PMID: 7529107Sep 1, 1994Paper

The effect of caffeine on prostaglandin output from the guinea-pig uterus

British Journal of Pharmacology
E K Naderali, N L Poyser

Abstract

1. Caffeine increased the outputs of prostaglandin F2 alpha (PGF2 alpha), PGE2 and 6-keto-PGF1 alpha from the guinea-pig uterus on days 7 and 15 of the oestrous cycle. The effect on PGE2 output depended on the age of the animals and was absent in younger guinea-pigs (< 4 months). Theophylline also stimulated the outputs of PGF2 alpha and 6-keto-PGF1 alpha, but not the output of PGE2, from the day 7 guinea-pig uterus. 2. The stimulatory effects of caffeine on the outputs of PGF2 alpha, PGE2 and 6-keto-PGF1 alpha from the guinea-pig uterus were not prevented by lack of extracellular calcium, ryanodine or ruthenium red (both inhibitors of calcium release via the ryanodine receptor), although the increase in PGF2 alpha output tended to be slower when extracellular calcium was absent. Also, ryanodine flattened and broadened the peak of increased PGF2 alpha release. 3. The calmodulin antagonists, W-7 and trifluoperazine, had no inhibitory effect on the caffeine-stimulated increases in uterine prostaglandin output. In fact, W-7 (but not trifluoperazine) greatly potentiated the action of caffeine on uterine PGF2 alpha output, but had little or no potentiating effect on the action of caffeine on uterine PGE2 and 6-keto-PGF1 alpha output...Continue Reading

References

Jan 26, 1978·The New England Journal of Medicine·D RobertsonJ A Oates
Jun 1, 1979·British Journal of Obstetrics and Gynaecology·M AkerlundM L Forsling
Oct 1, 1976·Physiological Reviews·E W Horton, N L Poyser
May 1, 1976·Prostaglandins·V LundströmN Wiqvist
Nov 1, 1976·Fertility and Sterility·R AntoniniC J Pauerstein
Nov 1, 1991·Journal of Reproduction and Fertility·F A Johnson, N L Poyser
Jan 1, 1991·The Journal of Membrane Biology·M Dehlinger-KremerI Schulz
Jun 1, 1987·The Journal of Endocrinology·S C Riley, N L Poyser
Sep 1, 1987·Journal of Reproduction and Fertility·N L Poyser
Jul 1, 1972·The Journal of Endocrinology·N L Poyser
Jan 1, 1981·Acta Veterinaria Scandinavica. Supplementum
Sep 1, 1983·Prostaglandins, Leukotrienes, and Medicine·I Downing, N L Poyser
May 1, 1981·Journal of Reproduction and Fertility·C A Phillips, N L Poyser
Sep 1, 1980·Journal of Reproduction and Fertility·N L Poyser, F M Scott
Mar 1, 1993·Trends in Pharmacological Sciences·V Sorrentino, P Volpe

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Citations

Sep 2, 1998·British Journal of Pharmacology·G DanialouJ Boczkowski
May 1, 1997·Prostaglandins, Leukotrienes, and Essential Fatty Acids·E K Naderali, N L Poyser
Jan 1, 1997·Prostaglandins, Leukotrienes, and Essential Fatty Acids·E K Naderali, N L Poyser
Dec 21, 2012·Journal of Investigative and Clinical Dentistry·Shabnam Soltani BozchaloeiMahvash Oskoui

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