The effect of cage stiffness on the rate of lumbar interbody fusion: an in vivo model using poly(l-lactic Acid) and titanium cages

Spine
Martijn van DijkP I J M Wuisman

Abstract

A goat interbody fusion model using poly-(L-lactic acid) and titanium cages was designed to evaluate the effect of cage stiffness on lumbar interbody fusion. To investigate the effect of cage stiffness on the rate of interbody fusion. Various types of cages considerably exceed the stiffness of vertebral bone, which ultimately may lead to postoperative complications. To avoid these complications, poly-(L-lactic acid) cages with limited stiffness have been designed. The mechanical integrity of the cages remains intact for at least 6 months. Interbody fusions were performed at L3-L4 of 15 Dutch milk goats, and one of three cages was randomly implanted: 1) a titanium cage (n = 3), 2) a stiff poly-(L-lactic acid) cage (n = 6), or 3) a flexible poly-(L-lactic acid) cage (n = 6). Interbody fusion was assessed radiographically by three independent observers 3 and 6 months after surgery. At 3 months, all the poly-(L-lactic acid) specimens showed ingrowth of new bone, but with radiolucency in the fusion mass. At 6 months, solid arthrodesis was observed in four of six poly-(L-lactic acid) specimens, advanced ingrowth in one specimen, and infection in one specimen. Titanium cages showed ingrowth of bone, but with radiolucency in the fusion...Continue Reading

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Citations

Nov 6, 2002·Journal of Biomedical Materials Research·M van DijkP I J M Wuisman
Aug 11, 2004·Spine·Robert PflugmacherFrank Kandziora
Sep 1, 2005·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·M SpruitR M Castelein
Oct 19, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Margriet G MullenderPaul I J M Wuisman
Aug 1, 2008·Journal of the Royal Society, Interface·M NavarroJ A Planell
May 7, 2013·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Dechao KongXiang Li
Oct 16, 2007·Journal of Neurosurgery. Spine·Mitsuru TakemotoTakashi Nakamura
Nov 10, 2009·Journal of Materials Science. Materials in Medicine·T H SmitL E Govaert
Nov 26, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Robert J KroezeMarco N Helder
Sep 15, 2016·Orthopaedic Surgery·Kevin Phan, Ralph J Mobbs
Feb 6, 2018·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Ying-Chun ChenWei Yuan
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Aug 5, 2003·Spine·Thomas A Zdeblick, Frank M Phillips
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Jan 20, 2010·Journal of Spinal Disorders & Techniques·Jyi-Feng ChenChieh-Tsai Wu
Jun 1, 2006·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Jean Y LazennecGérard Saillant
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Apr 28, 2011·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Dorothee HeidenreichBrigitte von Rechenberg
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Apr 7, 2007·Journal of Biomedical Materials Research. Part a·Chia-Ying LinScott J Hollister

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