The effect of calcium and vitamin D3 supplementation on the healing of the proximal humerus fracture: a randomized placebo-controlled study

Calcified Tissue International
A M DoetschB Danneskiold-Samsøe

Abstract

The purpose of this study was to (1) quantify the healing process of the human osteoporotic proximal humerus fracture (PHF) expressed in terms of callus formation over the fracture region using BMD scanning, and (2) quantify the impact of medical intervention with vitamin D3 and calcium on the healing process of the human osteoporotic fracture. The conservatively treated PHF was chosen in order to follow the genuine fracture healing without influence of osteosynthetic materials or casts. Thirty women (mean age = 78 years; range = 58-88) with a PHF, osteoporosis or osteopenia (based on a hip scan, WHO criteria), and not taking any drugs related to bone formation, including calcium or vitamin D supplementation, were randomly assigned to either oral 800 IU vitamin D3 plus 1 g calcium or placebo, in a double-blind prospective study. We measured biochemical, radiographic, and bone mineral density effect parameters to evaluate the impact on the healing process. Scanning procedures of the fractured shoulder included use of a fixation device to obtain the highest possible precision. Double scans of the fractured shoulder revealed a coefficient of variation (CV) on BMD measurements that improved from 2.8% immediately after fracture occu...Continue Reading

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References

Dec 1, 1992·Journal of Biomechanics·K Choi, S A Goldstein
Jul 22, 1995·Lancet·R P van der WielenW A van Staveren
Nov 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A Kanis
Jan 1, 1997·Archives of Orthopaedic and Trauma Surgery·H OmeroğluN Akkaş
Jan 7, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A D Delgado-MartínezL Munuera
Nov 24, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·H OmerogluY Ates
Dec 16, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S G Roberts, C R Steele
Nov 21, 2001·Clinical Biomechanics·C I MoorcroftR H Wade
Aug 10, 2002·Calcified Tissue International·A M DoetschB Danneskiold-Samsøe

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Citations

Nov 28, 2012·Archives of Orthopaedic and Trauma Surgery·J P KolbW Lehmann
May 11, 2011·Journal of Dental Research·J D BashutskiL K McCauley
Jan 1, 2013·ISRN Orthopedics·William J Rodriguez, Jason Gromelski
May 18, 2016·Journal of Clinical Orthopaedics and Trauma·Nevres Hürriyet AydoğanKadir Bahadır Alemdaroğlu
Apr 3, 2013·The Orthopedic Clinics of North America·Bryon Hobby, Mark A Lee
Jan 25, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Ufuk TatliSait Polat
Sep 19, 2012·Spine·Geoffrey E StokerLukas P Zebala
Mar 31, 2009·The Spine Journal : Official Journal of the North American Spine Society·Christian P DipaolaGlenn R Rechtine
Mar 27, 2007·Injury·T William AxelradThomas A Einhorn
Dec 6, 2005·Clinics in Sports Medicine·Michael C Koester, Kurt P Spindler
Nov 10, 2006·Experimental Gerontology·Reinhard GruberJeffrey O Hollinger
May 12, 2009·BJU International·Donald L TrumpCandace S Johnson
May 23, 2006·Journal of Biochemical and Biophysical Methods·E PetritzR Wintersteiger
Jan 18, 2006·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Ozgür ErdoganFiliz Cevlik
Oct 1, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V HegdeJ M Lane
Mar 11, 2015·Journal of Cellular and Molecular Medicine·Hsiang-Hsi HongTing-An Chou
Jul 12, 2005·Current Medical Research and Opinion·Christine SimonelliYa-Ting Chen
Dec 5, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A SebestyénI Boncz
Jan 24, 2014·Archives of Osteoporosis·Paolo ParchiMichele Lisanti
Mar 25, 2016·Journal of Orthopaedic Trauma·Benjamin R ChildsHeather A Vallier
Sep 14, 2016·Maturitas·Bradley A FoulkeHemant Pandit
Sep 21, 2016·Spinal Cord·J Lamarche, G Mailhot
Sep 28, 2016·Expert Opinion on Pharmacotherapy·Letizia Vannucci, Maria Luisa Brandi
May 13, 2015·Foot & Ankle Specialist·Andrew Bernhard, Jorge Matuk
May 1, 2011·Geriatric Orthopaedic Surgery & Rehabilitation·Daniel Eschle, André G Aeschlimann
Oct 16, 2013·Foot & Ankle International·Jeremy T SmithChristopher P Chiodo
Jan 23, 2017·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Jakob C ThorudDaniel C Jupiter
Oct 3, 2015·Foot & Ankle International·James D Michelson, Mark D Charlson
Apr 6, 2016·Foot & Ankle International·Kathryn M O'ConnorSandra E Klein
Jun 28, 2012·Foot & Ankle International·Michael P McCabeDavid R Richardson
Dec 22, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Neil BhambMelodie Metzger
Jan 15, 2014·The Cochrane Database of Systematic Reviews·Goran BjelakovicChristian Gluud
Sep 2, 2008·Journal of Orthopaedic Trauma·Cory CollingeLaura Gehrig
Dec 17, 2005·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Sally Pullman-Mooar, Pekka Mooar
Oct 2, 2013·The Open Orthopaedics Journal·James C WidnallMohammed Waseem
Jan 28, 2014·Journal of Orthopaedic Trauma·Benjamin S ZellnerCharles A Reitman
Apr 15, 2014·The Cochrane Database of Systematic Reviews·Alison AvenellDianne O'Connell
Aug 2, 2017·JBJS Reviews·Elaine Y TranAndrew J Rosenbaum
Nov 16, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Joseph L Roberts, Hicham Drissi
Jan 5, 2011·The Journal of Bone and Joint Surgery. British Volume·I R MurrayC M Robinson
Oct 5, 2018·JBMR Plus·Martin Blomberg JensenHenrik Kehlet

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