The effect of calcium citrate on bone density in the early and mid-postmenopausal period: a randomized placebo-controlled study

American Journal of Therapeutics
L A RumlC Y Pak

Abstract

This placebo-controlled randomized trial was conducted to ascertain the value of calcium citrate supplementation in averting bone loss in 63 postmenopausal women, 57 of whom were early postmenopausal (five years after menopause) and six of whom were mid-postmenopausal (five to ten years after menopause). Bone density data were available for 25 women who took 800 mg of calcium citrate daily and 31 women who received placebo for one to two years. The two groups were similar in baseline age, years postmenopause (3.3 in the calcium citrate group vs 2.7 in the placebo group), height, weight, calcium intake, and L2-L4 bone density. L2-L4 bone density did not change during calcium citrate treatment (+ 1.03% after two years), whereas it declined significantly by -2.38% after two years on placebo (P < .001). Femoral neck bone density did not change in either group. Radial shaft bone density did not change in the calcium citrate group (-0.02% after two years), but it declined significantly in the placebo group (-1.79% after one year and -3.03% after two years, P < .01). The difference in bone density of the L2-L4 vertebrae and radial shaft after two years of treatment was significant between the two groups. An analysis of covariance disc...Continue Reading

Citations

Nov 12, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Ellen C CusslerTimothy G Lohman
Jul 23, 2002·The Proceedings of the Nutrition Society·Richard Eastell, Helen Lambert
Apr 9, 2005·Southern Medical Journal·Julie McKee, Sara L Warber
Nov 17, 2019·Nutrients·Donatella GranchiRenata Caudarella
Mar 25, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J WuL Li
Jul 24, 2012·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Ondrej NikelDeepak Vashishth

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