The effect of caloric restriction on blood pressure and cardiovascular function: A systematic review and meta-analysis of randomized controlled trials.

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Amy A KirkhamCarla M Prado

Abstract

Preclinical evidence suggests that caloric restriction is an effective therapy for a number of cardiovascular insults. Whether caloric restriction has cardio-protective effects in humans is not well understood. The aim was to systematically review and meta-analyze human randomized control trials (RCTs) testing the effect of caloric restriction on blood pressure (BP) and cardiovascular function. A systematic review was performed using Medline, EMBASE, CINAHL (up to June 2017) to search for RCTs of adults receiving a calorie-restricted intervention versus a control/standard diet. Random-effect meta-analyses were performed to calculate weighted mean difference and 95% CI. Thirty-two RCTs with 1722 participants assessing BP (n = 29 studies), heart rate (n = 10), VO2peak (n = 8), muscle sympathetic nerve activity (MSNA, n = 4), and endothelial function (n = 4) were included. Calorie-restricted interventions lasting 1-4 weeks had the largest effect on systolic (-5.5 mmHg, p < 0.001, 95% CI: -3.8, -7.1) and diastolic (-2.9 mmHg, p = 0.005, 95% CI: -5.0, -0.9) BP, but no effect on HR. Interventions lasting 1.5-6 months had similar effects on BP, and reduced HR (-4.4 beats/minute, p < 0.001, 95% CI: -6.1,-2.8). Relative VO2peak improved...Continue Reading

References

Jul 1, 1988·The American Journal of Cardiology·S P FortmannP D Wood
Jun 1, 1987·American Heart Journal·W B KannelL A Cupples
Nov 1, 1994·International Journal of Sports Medicine·E J Velthuis-te WierikG Schaafsma
Sep 17, 1998·International Journal of Sport Nutrition·A C UtterC N Nieman
Apr 12, 2000·Acta Physiologica Scandinavica·H Hoppeler, E R Weibel
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Jan 6, 2005·JAMA : the Journal of the American Medical Association·Michael L DansingerErnst J Schaefer
Mar 3, 2005·The Journal of Nutritional Biochemistry·Mark P Mattson, Ruiqian Wan
May 11, 2005·The American Journal of Clinical Nutrition·Cara B EbbelingDavid S Ludwig
Mar 29, 2007·American Journal of Physiology. Endocrinology and Metabolism·Luigi FontanaUNKNOWN Washington University School of Medicine CALERIE Group
Aug 28, 2007·Journal of the American College of Cardiology·Kim FoxUNKNOWN Heart Rate Working Group
Oct 2, 2007·Toxicology and Applied Pharmacology·Mayurranjan S MitraHarihara M Mehendale
Jul 8, 2008·Atherosclerosis·Michael LefevreUNKNOWN Pennington CALERIE team
Jan 8, 2009·Medicine and Science in Sports and Exercise·Joseph E DonnellyUNKNOWN American College of Sports Medicine
Jul 11, 2009·Science·Ricki J ColmanRichard Weindruch
Dec 17, 2009·Medicine and Science in Sports and Exercise·D Enette Larson-MeyerEric Ravussin
Jun 4, 2010·Antioxidants & Redox Signaling·Leanne M Redman, Eric Ravussin
Aug 24, 2010·Acta Pharmacologica Sinica·Xuefeng Han, Jun Ren
Dec 2, 2010·Journal of Hypertension·Nora E StraznickyMarkus P Schlaich
Jan 14, 2011·Medicine and Science in Sports and Exercise·Stian Thoresen AspenesUlrik Wisløff
Apr 1, 2011·The New England Journal of Medicine·Dennis T VillarealKrupa Shah
May 19, 2011·Journal of Molecular and Cellular Cardiology·Ismayil AhmetMark I Talan
Jul 14, 2011·Biochimica Et Biophysica Acta·Vernon W Dolinsky, Jason R B Dyck
Jul 27, 2011·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Christi DeatonTiny Jaarsma
May 10, 2012·PloS One·Ph Gabriel StegUNKNOWN CLARIFY Investigators
Oct 17, 2012·PloS One·Maciej S BuchowskiL Jackson Roberts
Feb 22, 2013·The American Journal of Clinical Nutrition·Taylor C SalinardiSai Krupa Das
Jun 12, 2013·Journal of Cardiopulmonary Rehabilitation and Prevention·Connie W Bales, William E Kraus
Jul 5, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M BouchonvilleD T Villareal
Sep 21, 2013·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Nur Islami Mohd Fahmi TengWan Zurinah Wan Ngah
Feb 22, 2014·Acta Dermato-venereologica·Peter JensenLone Skov

❮ Previous
Next ❯

Citations

Nov 12, 2020·International Journal of Molecular Sciences·Pamela SenesiIleana Terruzzi
Apr 16, 2021·Frontiers in Cell and Developmental Biology·Xiaokang LiHaiyan Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.