The effect of captopril on lipopolysaccharide-induced lung inflammation

Experimental Lung Research
Javad BoskabadiM H Boskabady

Abstract

As an angiotensin converting enzyme (ACE) inhibitor, the effects of captopril on inflammation has been previously examined. Captopril has been shown to have anti-inflammatory and antioxidant effects. Imbalance in the oxidant/antioxidant system is one of the major causes of inflammation. In the present study, the effects of captopril on total and differential white blood cells (WBC), oxidative stress andlung histopathological changes produced by lipopolysaccharide (LPS) were investigated in rat. The rats were divided into: control (saline-treated), LPS (1 mg/kg), 12.5, 25 or 50 mg/kg captopril-treated before LPS administration (LPS+Cap12.5, LPS+Cap25 and LPS+Cap50) and Cap-treated, 50 mg/kg before saline administration (as positive control group)groups. The levels of total and percentage of differential WBC in blood, and the oxidative stress index in the serum were evaluated. Lung histopathological changes were also examined. In the LPS group, total WBC count, percentage of neutrophils, basophils, eosinophils, and monocytes in the blood, oxidative stress indices in serum, lung pathological changes were significantly higher than the control group (p < 0.05 to p < 0.001). Pathological changes of lung, serum oxidative stress indice...Continue Reading

References

Apr 20, 1999·Biochemical and Biophysical Research Communications·R KranzhöferW Kübler
Dec 22, 1999·Proceedings of the Society for Experimental Biology and Medicine·R A Floyd
Jan 3, 2001·The Journal of Clinical Investigation·P P Tak, G S Firestein
May 9, 2001·Current Opinion in Nephrology and Hypertension·M Ruiz-OrtegaJ Egido
Apr 30, 2002·Seminars in Immunology·Joseph P Mizgerd
Jul 31, 2002·Biochemical and Biophysical Research Communications·Natalia LaptevaKatsushi Tokunaga
Mar 9, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Derek W GilroyJamie D Croxtall
Sep 21, 2004·Annual Review of Plant Biology·Klaus Apel, Heribert Hirt
Mar 4, 2005·The American Journal of Pathology·Suzy A A ComhairSerpil C Erzurum
May 25, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Salvatore Cuzzocrea
Feb 28, 2006·European Journal of Pharmacology·Irfan RahmanAruna Kode
May 16, 2006·Experimental Eye Research·Iliyana IlievaShigeaki Ohno
Nov 24, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lou Ann S BrownTheresa W Gauthier
Jun 27, 2008·Trends in Pharmacological Sciences·Chiara MarchesiErnesto L Schiffrin
Nov 18, 2008·The European Respiratory Journal·P FuK G Birukov
Jan 1, 2008·Indian Journal of Nephrology·M PrakashR Prabhu
May 14, 2010·Journal of Inflammation·José L Miguel-CarrascoCarmen M Vázquez
Nov 10, 2010·The Journal of Clinical Investigation·Eric J MarrotteAlex F Chen
Jun 30, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M H BoskabadyG Byrami
Nov 29, 2012·Annals of Thoracic Medicine·Asrar AhmadQayyum Husain
Dec 7, 2013·Experimental & Molecular Medicine·Beom Seok Park, Jie-Oh Lee
Jun 4, 2014·Biochimica Et Biophysica Acta·Mark D TurnerDaniel J Pennington
Nov 28, 2014·Comprehensive Physiology·Joachim Roth, Clark M Blatteis
Dec 30, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Alaa N A FahmiHatem A Salem
Oct 30, 2016·BMC Veterinary Research·Øyvind SalvesenCecilie Ersdal
May 17, 2017·BioFactors·Farzaneh Shakeri, Mohammad Hossein Boskabady

❮ Previous
Next ❯

Citations

May 23, 2019·Respiratory Research·Saeideh SaadatMohammad Hossein Boskabady
Nov 6, 2020·Environmental Science and Pollution Research International·Mengchan ZhuJue Pan
Apr 17, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Mostafa BoskabadyMohammad Hossein Boskabady
Oct 1, 2020·Brain Research Bulletin·Amin Mokhtari-ZaerMohammad Hossein Boskabady

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.