The effect of carbamazepine on valproic acid disposition in adult volunteers

British Journal of Clinical Pharmacology
S K PanesarF S Abbott

Abstract

1. Pharmacokinetic parameters for valproic acid (VPA) were determined before and following 2 weeks of carbamazepine (CBZ) administration in five healthy male volunteers. Mean VPA dosage was 16.4 mg kg-1 day-1. CBZ dosage was started at 100 mg twice daily and increased after 1 week to a total daily dose of 300 mg. 2. After CBZ administration, mean VPA plasma clearance increased from 0.90 +/- 0.18 s.d. to 1.26 +/- 0.24 l h-1 (P less than 0.05) as did clearance of free VPA (20.8 +/- 7.6 to 37.0 +/- 13.6 l h-1). Mean VPA elimination rate constant increased from 0.051 +/- 0.011 to 0.067 +/- 0.011 h-1 (P less than 0.05) after CBZ administration. 3. Mean area under the serum concentration vs time curve decreased from 675.0 +/- 130.5 to 475.7 +/- 75.7 mg l-1 h (P less than 0.05) after CBZ administration. Mean serum VPA half-life decreased from 14.0 +/- 2.4 to 10.6 +/- 1.4 h (P less than 0.05). Mean serum VPA trough concentrations decreased from 44.0 +/- 16.7 to 27.0 +/- 10.4 micrograms ml-1 (P less than 0.05). 4. A significant change was not observed in the mean VPA volume of distribution after CBZ coadministration suggesting that enzyme induction rather than a competition for plasma protein binding sites was involved in this interacti...Continue Reading

References

Nov 1, 1979·Clinical Pharmacology and Therapeutics·T A BowdleR E Cutler
Jan 1, 1975·Drug Metabolism Reviews·P L Morselli, A Frigerio
Jan 1, 1986·Therapeutic Drug Monitoring·A M Baciewicz
Nov 1, 1986·Journal of Clinical Pharmacology·G M PollackD D Shen
Aug 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J Wagner, K Schmid
Nov 1, 1986·Journal of Clinical Pharmacology·S Oie
Jan 1, 1985·Biopharmaceutics & Drug Disposition·M BialerF Pachys
May 1, 1985·Pharmacotherapy·E M Rimmer, A Richens
Jan 1, 1985·Clinical Pharmacokinetics·M EichelbaumL Bertilsson
Jan 1, 1983·Drug Metabolism Reviews·G R Wilkinson
Sep 1, 1984·British Journal of Clinical Pharmacology·E PeruccaA Richens
Aug 1, 1983·British Journal of Clinical Pharmacology·W G RapeportM J Brodie
Jan 1, 1981·European Journal of Clinical Pharmacology·F HoffmannB C Jancik
Jan 1, 1982·Therapeutic Drug Monitoring·G F MattsonJ A Cramer

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Citations

Sep 14, 2001·European Journal of Drug Metabolism and Pharmacokinetics·U KreherF Wien
Jan 1, 1991·Pharmacology & Therapeutics·J O Miners, P I Mackenzie
May 13, 1999·Journal of Clinical Pharmacy and Therapeutics·B B SerranoA Domínguez-Gil
Jun 1, 1997·Environmental Health Perspectives·B Burchell, M W Coughtrie
Sep 28, 2007·Therapeutic Drug Monitoring·Angela K BirnbaumIlo E Leppik

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