The Effect of Carbetocin Dose on Transmural Dispersion of Myocardial Repolarization in Healthy Parturients Scheduled for Elective Cesarean Delivery Under Spinal Anesthesia: A Prospective, Randomized Clinical Trial.

Anesthesia and Analgesia
Natasha Clunies-RossAnthony Chau

Abstract

QT interval prolongation is associated with torsade de pointes but remains a poor predictor of drug torsadogenicity. Increased transmural dispersion of myocardial repolarization (TDR), measured as the time interval between the peak and end of the T wave (Tp-e), is a more reliable predictor. Carbetocin is recommended as an uterotonic in patients undergoing cesarean delivery (CD), but its effect on Tp-e is unknown. We evaluated the effect of carbetocin dose on Tp-e and Bazett-corrected QT intervals (QTc) during elective CD under spinal anesthesia. On patient consent, 50 healthy parturients undergoing elective CD with a standardized spinal anesthetic and phenylephrine infusion were randomized to receive an intravenous (IV) bolus of carbetocin 50 µg (C50) or 100 µg (C100) via an infusion pump over 1 minute. A 12-lead electrocardiogram (ECG) was obtained at baseline, 5 minutes after spinal anesthesia, then 5 and 10 minutes after carbetocin administration. A cardiologist blinded to group and timing of ECGs measured QTc and Tp-e using Emori's criteria. Primary outcome was the change in Tp-e at 5 minutes after carbetocin administration between the C50 and C100 groups and within each group compared to baseline values. Secondary outcomes...Continue Reading

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References

Apr 16, 1998·Journal of Electrocardiology·C AntzelevitchS Sicouri
Jan 5, 2002·Basic Research in Cardiology·C Antzelevitch, J Fish
Jan 19, 2002·Journal of Cardiovascular Electrophysiology·T Emori, C Antzelevitch
Oct 8, 2004·Clinical Pharmacology and Therapeutics·Beny CharbitJean Marty
Jul 24, 2008·Anesthesiology·Beny CharbitChristian Funck-Brentano
Jun 9, 2009·British Journal of Anaesthesia·E LangesaeterA Stubhaug
Sep 29, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·M JonssonS Nordén-Lindeberg
Oct 21, 2009·Circulation·Peter J SchwartzCarla Spazzolini
Nov 28, 2009·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Dean LeducUNKNOWN CLINICAL PRACTICE OBSTETRICS COMMITTEE
Feb 10, 2010·Circulation·Barbara J DrewUNKNOWN American Heart Association Acute Cardiac Care Committee of the Council on Clinical Cardiology, the Council on Cardiovascular
Feb 13, 2010·British Journal of Anaesthesia·A J ButwickB Carvalho
Aug 21, 2013·International Journal of Obstetric Anesthesia·M BruyereB Charbit
Nov 28, 2013·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Mubeen KhanJose C A Carvalho
May 16, 2014·Current Cardiology Reviews·Pieter G Postema, Arthur A M Wilde
Feb 19, 2015·Pharmacology Research & Perspectives·Yusheng QuHugo M Vargas
Jun 19, 2015·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Asli TanindiCandan Iltemir Duvan
Dec 12, 2018·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Dean LeducAndré B Lalonde

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Citations

Nov 18, 2020·British Journal of Clinical Pharmacology·Dongmei SunFacundo Garcia-Bournissen
Aug 21, 2021·The Canadian Journal of Cardiology·Christopher C CheungAndrew D Krahn

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