PMID: 653739Feb 1, 1978Paper

The effect of carcinogens on the nuclear size of HeLa cells

Toxicology
C E Agrelo

Abstract

The size of HeLa S-3 cell nuclei was measured after 1--3 days in culture. After exposure to carcinogens, nuclear size increased and the frequency distribution pattern of nuclear size changed. The optimal conditions for these changes were the use of concentrations of chemicals which had a low order of cytotoxicity and the measurement of nuclear size 48 h after pulse treatment of the cells for 30--60 min. These effects were not seen with non-carcinogens. The results obtained suggest that changes in nuclear size may be an index of chemical carcinogenicity.

References

Apr 1, 1976·Chemico-biological Interactions·J V Frei
Jun 28, 1976·Histochemistry·L EnerbäckK Norrby
Jan 1, 1969·International Review of Cytology·R Carriere
Dec 1, 1973·Journal of Microscopy·W M Cowan, D F Wann

❮ Previous
Next ❯

Citations

Jan 1, 1991·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A J FowlieP Grasso
Oct 1, 1994·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C WestmorelandP Grasso
Feb 24, 2010·Journal of the American Chemical Society·Philip HowesMary Hughes
Sep 16, 1980·Biochemical and Biophysical Research Communications·G A ClawsonE A Smuckler
Oct 15, 1982·Biochemical and Biophysical Research Communications·G A Clawson, E A Smuckler
Oct 14, 2016·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Kenji TakeshitaToshinari Maeda
Aug 8, 2017·SLAS Discovery·Jeanne Chiaravalli, J Fraser Glickman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.