The effect of cardiac output on the pharmacokinetics and pharmacodynamics of propofol during closed-loop induction of anesthesia.

Computer Methods and Programs in Biomedicine
A SavocaGuy A Dumont

Abstract

Intraoperative hemodynamic stability is essential to safety and post-operative well-being of patients and should be optimized in closed-loop control of anesthesia. Cardiovascular changes inducing variations in pharmacokinetics may require dose modification. Rigorous investigational tools can strengthen current knowledge of the anesthesiologists and support clinical practice. We quantify the cardiovascular response of high-risk patients to closed-loop anesthesia and propose a new application of physiologically-based pharmacokinetic-pharmacodynamic (PBPK-PD) simulations to examine the effect of hemodynamic changes on the depth of hypnosis (DoH). We evaluate clinical hemodynamic changes in response to anesthesia induction in high-risk patients from a study on closed-loop anesthesia. We develop and validate a PBPK-PD model to simulate the effect of changes in cardiac output (CO) on plasma levels and DoH. The wavelet-based anesthetic value for central nervous system monitoring index (WAVCNS) is used as clinical end-point of propofol hypnotic effect. The median (interquartile range, IQR) changes in CO and arterial pressure (AP), 3 min after induction of anesthesia, are 22.43 (14.82-36.0) % and 26.60 (22.39-35.33) % respectively. The ...Continue Reading

References

Jan 1, 1992·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P A GrayP J Simons
Nov 1, 1991·British Journal of Anaesthesia·J E FairfieldR J Beale
Jan 1, 1988·British Journal of Anaesthesia·M A ClaeysF Camu
Feb 1, 1988·British Journal of Anaesthesia·T KirkpatrickW S Nimmo
Mar 12, 1999·British Journal of Clinical Pharmacology·J X Mazoit, K Samii
Jul 27, 2005·British Journal of Clinical Pharmacology·Haruhiko HiraokaRyuya Horiuchi
Aug 24, 2005·Anesthesia and Analgesia·David L ReichCarol A Bodian
Aug 28, 2007·Anesthesiology·Michel M R F StruysSteven L Shafer
Nov 2, 2012·Anesthesiology·Jean-Louis Vincent, David Fagnoul
Jan 29, 2014·Computer Methods and Programs in Biomedicine·F N NogueiraP Rocha
Apr 18, 2014·Anaesthesia·L I Cortínez
May 24, 2015·British Journal of Anaesthesia·M J DevinneyR D Sanders
Oct 28, 2016·Biopharmaceutics & Drug Disposition·Piotr SmuszkiewiczAgnieszka Bienert
May 13, 2017·Computer Methods and Programs in Biomedicine·Fabrizio PadulaGiulio Vivacqua
Dec 7, 2017·Anesthesia and Analgesia·Nicholas WestRichard N Merchant
Apr 18, 2018·British Journal of Anaesthesia·D J EleveldM M R F Struys
Mar 19, 2019·Anesthesia and Analgesia·John C Drummond

❮ Previous
Next ❯

Citations

Jan 16, 2021·Drug Delivery and Translational Research·Richa SharmaDeepak Joshi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Jin-Oh HahnJ Mark Ansermino
Journal of Cardiothoracic and Vascular Anesthesia
P CerianaA Bartoli
© 2021 Meta ULC. All rights reserved