PMID: 1212000Dec 1, 1975Paper

The effect of cardiopulmonary bypass perfusion pressure on myocardial gas tensions in the presence of coronary stenosis

The Annals of Thoracic Surgery
S F KhuriV L Gott

Abstract

Mass spectrometry was utilized to determine myocardial gas tensions in dogs subjected to cardiopulmonary bypass. Myocardial ischemia occurred in animals with normal coronary arteries when cardiopulmonary bypass perfusion pressure fell 40 to 60 mm Hg below the mean aortic pressure measured prior to bypass. Myocardial ischemia did not occur, or could be eliminated when present, if cardiopulmonary bypass perfusion pressure was maintained near prebypass mean aortic pressure. In animals with constricted circumflex coronary arteries, the adverse effect of low perfusion pressure on myocardial metabolism during cardiopulmonary bypass was found to be more severe in areas of myocardium supplied by the stenotic coronary artery. It is concluded that maintenance of cardiopulmonary bypass perfusion pressure near the level of preoperative mean aortic pressure will help prevent myocardial ischemia during operation; particularly in patients with coronary artery disease.

References

Mar 15, 1973·The New England Journal of Medicine·E L AldermanD C Harrison
Jan 1, 1973·Circulation·D L BrewerA G Bartel
Feb 1, 1973·American Heart Journal·H N HultgrenW W Angell
Feb 1, 1972·Journal of Applied Physiology·J W BrantiganM N Martz
Mar 1, 1968·The Annals of Thoracic Surgery·E B DiethrichM E De Bakey

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Citations

Jan 16, 2002·The Annals of Thoracic Surgery·K R KhabbazK G Warner
Jan 29, 2005·The Journal of Thoracic and Cardiovascular Surgery·Shukri F KhuriWilliam G Henderson
Aug 10, 2004·Surgery·Dharam J KumbhaniShukri F Khuri
Oct 1, 1987·The Journal of Surgical Research·S Y SiouffiS F Khuri
Sep 1, 1979·Circulation Research·R B CaseF S Castellana
Jan 1, 1979·Scandinavian Journal of Thoracic and Cardiovascular Surgery·J JalonenJ Niinikoski
Jan 1, 1980·Scandinavian Journal of Thoracic and Cardiovascular Surgery. Supplementum·J Jalonen

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