The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group

The New England Journal of Medicine
M PackerN H Shusterman

Abstract

Controlled clinical trials have shown that beta-blockers can produce hemodynamic and symptomatic improvement in chronic heart failure, but the effect of these drugs on survival has not been determined. We enrolled 1094 patients with chronic heart failure in a double-blind, placebo-controlled, stratified program, in which patients were assigned to one of the four treatment protocols on the basis of their exercise capacity. Within each of the four protocols patients with mild, moderate, or severe heart failure with left ventricular ejection fractions < or = 0.35 were randomly assigned to receive either placebo (n = 398) or the beta-blocker carvedilol (n = 696); background therapy with digoxin, diuretics, and an angiotensin-converting-enzyme inhibitor remained constant. Patient were observed for the occurrence death or hospitalization for cardiovascular reasons during the following 6 months, after the beginning (12 months for the group with mild heart failure). The overall mortality rate was 7.8 percent in the placebo group and 3.2 percent in the carvedilol group; the reduction in risk attributable to carvedilol was 65 percent (95 percent confidence interval, 39 to 80 percent; P < 0.001). This finding led the Data and Safety Monit...Continue Reading

References

Feb 1, 1978·The American Journal of Cardiology·J A Thomas, B H Marks
Oct 1, 1975·British Heart Journal·F WaagsteinI Wallentin
Jan 11, 1990·European Journal of Clinical Pharmacology·R R RuffoloA J Nichols
Aug 1, 1991·The New England Journal of Medicine·UNKNOWN SOLVD InvestigatorsJay N Cohn
Sep 27, 1984·The New England Journal of Medicine·J N CohnT Rector
May 1, 1995·Journal of the American College of Cardiology·S L OlsenM R Bristow
Dec 1, 1994·Circulation·W J ManningP S Douglas
Mar 25, 1993·The American Journal of Cardiology·E M GilbertM R Bristow
Mar 15, 1994·Journal of the American College of Cardiology·M L FisherB P Hamilton
Jul 15, 1993·The New England Journal of Medicine·A M FeldmanR P Bain

❮ Previous
Next ❯

Citations

Dec 10, 2008·Archives of Internal Medicine·Lesley H CurtisAdrian F Hernandez
Dec 13, 2000·Statistics in Medicine·G D PinnaM Sanarico
Sep 27, 2002·Statistics in Medicine·David L DeMets
Jun 8, 2001·Biochemical and Biophysical Research Communications·T KawadaT Toyo-oka
Nov 1, 1996·Cardiovascular Drugs and Therapy·R FerrariO Visioli
Jan 1, 1997·Cardiovascular Drugs and Therapy·P Vantrimpont, J L Rouleau
Mar 29, 2000·Cell Biochemistry and Biophysics·D J Choi, H A Rockman
Apr 20, 2000·Indian Journal of Pediatrics·S C Chen
Apr 1, 2006·Tijdschrift voor gerontologie en geriatrie·C W Middeljans-Tijssen, R W M M Jansen
Aug 14, 2002·Irish Journal of Medical Science·G A MacGowan, D M McNamara
Feb 21, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Gerald W Dorn
Oct 6, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Jin-Shiung ChengChung-Ren Jan
May 8, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Finn Olav Levy
Oct 8, 2008·European Journal of Clinical Pharmacology·Junichi Azuma, Shinpei Nonen
Jan 1, 1997·European Journal of Clinical Pharmacology·L M Van BortelL G Van Nueten
Feb 4, 2006·The Journal of Membrane Biology·R MarchioliUNKNOWN GISSI-Prevenzione Investigators
Jun 4, 2010·Pediatric Cardiology·Jondavid MenteerRonald M Harper
Jul 29, 2005·Zeitschrift für Kardiologie·U C HoppeUNKNOWN Vorstand der Deutschen Gesellschaft fur Kardiologie--Herz- und Kreislaufforschung e.V
Apr 7, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·M BöhmM Kindermann
Aug 19, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·D KovacićM Podbregar
Mar 19, 2009·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Veselin MitrovicChristian Wilhelm Hamm
Oct 29, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Julia LemmerUNKNOWN German Competence Network for Congenital Heart Defects
Jun 21, 2011·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Paul A SobotkaHenry Krum
May 7, 2011·Basic Research in Cardiology·Johanna SchneiderRalf Gilsbach
Aug 6, 2009·Archives of Gynecology and Obstetrics·Melita MoioliSimone Ferrero
Jun 10, 2005·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Murray Esler, Tye Dawood
Jul 21, 2005·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Graeme Eisenhofer
Oct 3, 2006·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·D G Benditt, UNKNOWN Ad Hoc Syncope Consortium
Feb 2, 2008·Bulletin of Experimental Biology and Medicine·V A PenniyainenV A Tsyrlin
Dec 16, 2006·The International Journal of Cardiovascular Imaging·Sakir ArslanHuseyin Senocak
Mar 17, 2005·Cardiovascular Drugs and Therapy·R M A van de WalD J van Veldhuisen
Jul 19, 2005·Cardiovascular Drugs and Therapy·Daniel NulUNKNOWN Grupo de Estudio de la Sobrevida en la Insuficiencia Cardiaca en Argentina
Dec 31, 2005·Cardiovascular Drugs and Therapy·Takashi KohnoSatoshi Ogawa
Jan 22, 2008·Cardiovascular Drugs and Therapy·Emmanuel M KanoupakisPanos E Vardas
Oct 1, 2009·Cardiovascular Drugs and Therapy·Piergiuseppe AgostoniMauro Contini
Jul 3, 2010·Cardiovascular Drugs and Therapy·Willem J Remme
Jun 11, 2005·Heart Failure Reviews·Justine I DaviesAllan D Struthers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.