The effect of CASP3 rs4647610 and rs4647602 polymorphisms on tumour size and cancer stage in papillary thyroid carcinoma.

British Journal of Biomedical Science
Z HeidariSaeedeh Salimi

Abstract

Papillary thyroid carcinoma (PTC) is the most frequent form of thyroid cancer whose incidence has increased in recent years. Dysregulated apoptosis is known in the pathogenesis of various cancers. Caspase-3 is an important apoptotic component and its abnormal function may play a key role in cancer pathogenesis. We tested the hypothesis of a link between CASP3 single nucleotide polymorphisms rs4647610 and rs4647602 on PTC and its clinical outcomes. A total of 134 PTC patients and 151 healthy controls were genotyped for CASP3 rs4647610 and rs4647602 single nucleotide polymorphisms (SNPs) using PCR-RFLP method. Allele and genotype frequencies of both SNPs were not different between cases and controls. The combined genotypes and haplotypes were not linked to PTC. However, the frequencies of CASP3 rs4647610 GA and AA genotypes were higher in PTC patients with larger tumour size (≥1 cm), and the rs4647610 SNP was associated with increased tumour size in the dominant model (OR 3.4 [95% CI, 1.1-11], P = 0.04). The CASP3 rs4647602CA and AA genotypes were higher in PTC patients with lower TNM stage (I-II) compared to higher stages (III-IV). No association was observed between CASP3 polymorphisms and other PTC outcomes. Although CASP3 rs4...Continue Reading

References

Oct 31, 2003·Essays in Biochemistry·Boris Zhivotovsky
May 6, 2004·Human Genetics·Young Hwa SoungSug Hyung Lee
Jun 15, 2007·Toxicologic Pathology·Susan Elmore
Jan 30, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Aziza NassarCynthia Cohen
Apr 3, 2008·Hematological Oncology·H Dean HosgoodQing Lan
May 7, 2008·Journal of Cellular Biochemistry·Jessica PlatiRoya Khosravi-Far
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kexin ChenQingyi Wei
Apr 2, 2011·Cell Death and Differentiation·M Olsson, B Zhivotovsky
Jun 15, 2011·DNA and Cell Biology·Rama Devi MittalRaju K Mandal
Jun 28, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R D MittalA Mandhani
Sep 29, 2011·Journal of Experimental & Clinical Cancer Research : CR·Rebecca S Y Wong
Dec 19, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·S Leena SankariM Elumalai
Jun 6, 2013·Journal of Cancer Epidemiology·Gabriella PellegritiRiccardo Vigneri
Jul 10, 2013·BMC Cell Biology·Matthew BrentnallLawrence H Boise
Mar 4, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Evelyn WinterTânia Beatriz Creczynski-Pasa
Jul 12, 2014·BioMed Research International·Mohamed HassanNoriaki Sakuragi
Jan 14, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Benyuan DengHanteng Yang
Dec 14, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Anne-Michelle NooneLynne Penberthy
Jan 24, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Xin GuoWei Guo
May 31, 2017·International Journal of Endocrinology·Yihao LiuHaipeng Xiao
Mar 5, 2018·International Journal of Surgery·Kuo-Hung HuangMuh-Hwa Yang
Mar 23, 2018·Proceedings. Biological Sciences·Beata UjvariThomas Madsen
Jan 1, 2019·International Journal of Endocrinology·Rafael Martins de MoraisOtávio de Toledo Nóbrega

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Dec 1, 2020·British Journal of Biomedical Science·N W BrownA Rhodes

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