The effect of catecholamines on the in vivo and in vitro responses of the cat lung during anaphylaxis

British Journal of Pharmacology
H W Mitchell, M P Sparrow

Abstract

1. Anaphylaxis in the lung of cats actively sensitized to Ascaris antigen has been investigated in vivo and in vitro. 2. In vivo there was a 100% increase in airways resistance and a 50% decrease in dynamic lung compliance following intravenous challenge with Ascaris antigen. Prostaglandin F2alpha induced similar changes but with histamine only dynamic lung compliance was affected. (-)-Isoprenaline prevented these prostaglandin F2alpha- and histamine-induced changes and caused a delay of about 2 min in the onset of the mechanical changes following anaphylactic challenge. 3. In vitro the isolated lung strip contracted within seconds of challenge whereas there was a delay of 2 to 3 min in the onset of the tracheal anaphylactic response. (-)-Isoprenaline, (-)-adrenaline and (+/-)-noradrenaline reduced the magnitude of anaphylactic contractions of the isolated trachea but did not significantly affect those of the isolated lung strip. This indicated lack of inhibition of mediator release from the lung parenchyma. 4. Histamine was released from sensitized lung fragments following challenge with the Ascaris extract. This release constituted 6.3% of the total tissue histamine and was not inhibited by (-)-isoprenaline (1 micrometer). 5....Continue Reading

References

Feb 15, 1979·European Journal of Pharmacology·H W Mitchell, M A Denborough
May 1, 1979·Clinical and Experimental Pharmacology & Physiology·H W Mitchell, M A Denborough
May 1, 1982·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·A Cebulska-WasilewskaK H Chadwick
Aug 1, 1981·Experimental Lung Research·J N Evans, K B Adler

Citations

Jun 1, 1976·European Journal of Pharmacology·M C Holroyde, P Eyre
Sep 1, 1975·British Journal of Pharmacology·J B FarmerA M Woods
Jan 1, 1975·Journal of Applied Physiology·D Dain, W M Gold
Apr 1, 1975·European Journal of Pharmacology·L Sörenby
Jan 1, 1971·International Archives of Allergy and Applied Immunology·E S Assem, H O SCHILD
Aug 1, 1971·British Journal of Pharmacology·E S Assem, H O SCHILD
Sep 1, 1972·The Journal of Experimental Medicine·M KalinerK F Austen
Apr 1, 1974·Acta Pharmacologica Et Toxicologica·L Sörenby
Feb 1, 1970·British Journal of Pharmacology·W C Bowman, M T Hall
Jun 1, 1973·The Journal of Allergy and Clinical Immunology·V PopaA Bouhuys
Mar 1, 1953·British Journal of Pharmacology and Chemotherapy·M D MCDOUGAL, G B WEST
Jan 1, 1963·International Archives of Allergy and Applied Immunology·A AKCASU
Nov 1, 1963·The Journal of Physiology·K A EDMAN, H O SCHILD

Related Concepts

Histamine Measurement
In Vivo
Anaphylaxis (Non Medication)
Lung
Catecholamine [EPC]
Airway Resistance
Entire Lung Parenchyma
Serotonin
Catecholamines Measurement
Contraction (Finding)

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