The effect of CD28/B7 blockade on alloreactive T and B cells after liver cell transplantation

Transplantation
B ReddyA Davidson

Abstract

Hepatocyte cell lines are beginning to be developed as universal donors for isolated liver cell transplantation, which is a less invasive method than orthotopic liver transplantation for treatment of metabolic liver disease. The immune response to isolated liver cell transplantation and its modification by costimulatory blockade are as yet not well delineated. Adenovirus expressing CTLA4Ig was used to study blockade of the costimulatory CD28/B7 pathway in murine models of hepatocyte transplantation, and the effects on alloreactive T and B cells were studied. CTLA4Ig delayed rejection of subcutaneously administered C57L-derived murine hepatoma cells in CBA/J recipients for >50 days. Activation and cytokine secretion by allospecific CD4+ and CD8+ T cells were initially blocked by CTLA4Ig; delayed rejection was associated with tumor infiltration by CD8+ T cells that did not secrete interferon-gamma. CTLA4Ig failed to block transplant rejection in primed mice, indicating that memory effector T cells were resistant to its action. In contrast, CTLA4Ig suppressed both naive and memory alloreactive B cells. High levels of CTLA4Ig mediated acceptance of hepatoma cells delivered directly into the spleen. However, isolated primary C57BL/6...Continue Reading

References

Jul 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R P VemuruS Gupta
May 1, 1995·The Journal of Experimental Medicine·M H SayeghL A Turka
Jan 1, 1994·Annual Review of Immunology·P Matzinger
Apr 1, 1996·The Journal of Experimental Medicine·S ValituttiA Lanzavecchia
Oct 31, 1996·The New England Journal of Medicine·H Reiser, M J Stadecker
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·H AzumaM H Sayegh
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·M G von HerrathM S Horwitz
Apr 1, 1998·Nature·J Banchereau, R M Steinman
May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y IlanJ R Chowdhury
May 23, 1998·Annual Review of Immunology·I S Grewal, R A Flavell
Jun 17, 1998·The Journal of Clinical Investigation·A ChandrakerM H Sayegh
Jun 25, 1998·Current Opinion in Immunology·D Tarlinton
Jan 12, 1999·Transplantation·G L BumgardnerC G Orosz
Jun 1, 1999·Seminars in Liver Disease·S C StromI J Fox
Oct 6, 1999·Current Opinion in Immunology·Z Dai, F G Lakkis
Dec 22, 1999·The Journal of Clinical Investigation·J TrambleyC P Larsen
Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J J BrownJ Roy-Chowdhury
Jul 6, 2000·The Journal of Clinical Investigation·M MiharaA Davidson

❮ Previous
Next ❯

Citations

Dec 7, 2002·Seminars in Cell & Developmental Biology·Sanjeev Gupta, Jayanta Roy Chowdhury
Nov 7, 2012·Transplantation·Gillian KinnearKathryn J Wood
May 13, 2006·Journal of Zhejiang University. Science. B·Zhao-lun LiJun Wu
Apr 13, 2005·American Journal of Veterinary Research·Lillian R AronsonNicola Mason
May 26, 2004·Transplant Immunology·Sanjeev GuptaDaniel Benten
May 3, 2003·Annals of the New York Academy of Sciences·Anne DavidsonJayashree Sinha
Dec 17, 2014·Immunity, Inflammation and Disease·Anne-Kristin HeningerJutta Schröder-Braunstein
Dec 8, 2004·Journal of Hepatology·Patrizia BurraSanjeev Gupta
Apr 12, 2002·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jayanta Roy-Chowdhury, Marshall S Horwitz
Apr 6, 2005·Lupus·A DavidsonD Daikh
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michal F TomczakBruce H Horwitz
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaobo WangAnne Davidson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.