The effect of centrally administered CCK-receptor antagonists on food intake in rats

Physiology & Behavior
E S CorpG P Smith

Abstract

Cholecystokinin (CCK) receptors are classified as two subtypes, designated CCK(A) and CCK(B), and both subtypes are found in brain and peripheral tissues of rats. CCK-8 has been shown to act peripherally to reduce meal size, and this satiating action can be blocked by CCK(A)-receptor antagonists. Recent evidence suggests that, in addition to the peripheral action of CCK, central CCK mechanisms may also be involved in satiety. Central administration of proglumide, a mixed CCK-receptor antagonist (CCK(A) > CCK(B)) has been shown to increase food intake and block the satiating effect of peripherally administered CCK-8 (15). In an attempt to replicate and extend these results, rats were given injections of proglumide or selective CCK-receptor antagonists into the lateral ventricle prior to a peripheral injection of CCK-8 or saline. Only proglumide stimulated an increase in 30-min test meal intake and attenuated the satiating effect of CCK-8. Two selective CCK(A)-receptor antagonists, lorglumide and devazepide, did not increase intake significantly when given alone, and they did not attenuate the effect of peripherally administered CCK-8. The selective CCK(B)-receptor antagonist, L365,260, reduced intake at all doses tested except t...Continue Reading

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S A WankT Slattery
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S A WankA de Weerth
Jan 1, 1986·Brain Research·T H MoranP R McHugh
Jan 1, 1985·Annals of the New York Academy of Sciences·J F RehfeldK Stengaard-Pedersen
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·W F HahneJ D Gardner
Nov 1, 1981·Endocrinology·R W Steigerwalt, J A Williams
Jan 1, 1994·Peptides·J N Crawley, R L Corwin

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Citations

Nov 12, 1998·Physiology & Behavior·D Dorré, G P Smith
Feb 15, 2000·Regulatory Peptides·M CovasaR C Ritter
May 10, 2015·Neurotoxicology·Bruno LebrunMichel Dallaporta
May 13, 2009·Molecular and Cellular Endocrinology·Felix Grün, Bruce Blumberg
Jul 7, 2005·Basic & Clinical Pharmacology & Toxicology·Charlotte Erlanson-Albertsson
Jan 1, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roger D ReidelbergerMartin Hulce
May 15, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert C Ritter
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J I Fratucci De GobbiJ V Menani

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