PMID: 8968296Jan 1, 1996Paper

The effect of cetirizine on the integrin-dependent respiratory burst of normodense eosinophils

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
G L PiacentiniA L Boner

Abstract

It has been proposed that cetirizine inhibits eosinophil migration and adherence. We evaluated the possible effect of cetirizine on integrin-induced eosinophil proinflammatory activation. Normodense eosinophils were triggered with monoclonal antibodies to integrins in the presence of different concentrations of certirizine. Proinflammatory activation was measured by evaluation of O2- production. Only at high concentrations (250 micrograms/ml) and in the first 15 min did certirizine significantly inhibit (p < 0.02) the eosinophil respiratory burst. No effect was shown for lower concentrations (50 and 100 micrograms/ml) or after 15 min. These data suggest that, only at very high concentrations, cetirizine may induce a transient inhibition of the integrin-induced eosinophil respiratory burst.

References

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Citations

Dec 31, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G M Walsh
Dec 21, 2013·International Journal of Immunopathology and Pharmacology·D G PeroniG L Piacentini

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