The effect of chain length and lipid phase transitions on the selective permeability properties of liposomes.

Biochimica Et Biophysica Acta
M C BlokJ De Gier

Abstract

This paper describes experiments showing the importance of the fatty acid chain length on the barrier properties of liposomal bilayers, prepared from saturated lecithins, under conditions of lateral phase separation. 1. Above the gel to liquid crystalline phase transition temperature, liposomes prepared from saturated lecithins with 14 or more carbon atoms per acyl chain exist as stable bilayers, which are practically impermeable to ions. 2. At temperatures well above the transition temperature dilauroyl phosphatidylcholine liposomes exhibited osmotic shrinkage, which was dependent on the ionic size of the solute used to bring about the osmotic gradient, indicating that the permeation through these less stable bilayers takes place mainly via individual diffusion of the permeating ions. 3. An enhanced release of trapped potassium from liposomes was demonstrated in the vicinity of the transition temperature. The extent of the increase, however, depended strongly on the length of the paraffin chain. 4. From measurements of the shrinkage behaviour of liposomes in the vicinity of the transition temperature it is concluded that the increased permeability decreases with increasing diameter of the permeating ion. This finding implies t...Continue Reading

References

Jan 1, 1974·Annual Review of Biochemistry·S J Singer
Jun 5, 1973·Biochemistry·E J Shimshick, H M McConnell
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·C D LindenC F Fox
Jan 1, 1974·Advances in Lipid Research·B Fourcans, M K Jain
Apr 29, 1974·Biochimica Et Biophysica Acta·J A Op den KampL L van Deenen
Oct 23, 1972·Biochimica Et Biophysica Acta·C W HaestL L van Deenen
Jul 6, 1973·Biochimica Et Biophysica Acta·P H VervergaertL L van Deenen
Jul 17, 1973·Biochemical and Biophysical Research Communications·H Hauser, M D Barratt
Jul 31, 1974·Biochimica Et Biophysica Acta·P Nicholls, N Miller
Jan 1, 1964·Advances in Lipid Research·L L van Deenen, G H de Haas
Jan 6, 1970·Biochimica Et Biophysica Acta·M C PhillipsD Chapman
Feb 2, 1971·Biochimica Et Biophysica Acta·M B Abramson
Jun 11, 1968·Biochimica Et Biophysica Acta·J de GierL L van Deenen

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Next ❯

Citations

Oct 1, 1990·Digestive Diseases and Sciences·J J Romero, L M Lichtenberger
May 29, 2007·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·H H ZepikD Deamer
Jul 21, 2001·Biophysical Journal·E Sparr, H Wennerström
Dec 18, 2001·Advanced Drug Delivery Reviews·K Kono
Jul 25, 2003·International Journal of Pharmaceutics·Mysore P RamprasadNandini V Katre
Jun 29, 2013·Environmental Science & Technology·Loice M Ojwang', Robert L Cook
Jul 18, 2012·ACS Nano·Karmena JaskiewiczAnja Kroeger
Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A F EsserH J Müller-Eberhard
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J H CroweL M Crowe
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·J A VirtanenP Somerharju
Jan 1, 1984·Cancer Drug Delivery·R L Magin, M R Niesman
May 1, 1977·Plant Physiology·B D McKersie, J E Thompson
Jul 22, 2006·Biochemical and Biophysical Research Communications·Yan-Liang ZhangMirianas Chachisvilis
Nov 8, 2011·Lasers in Surgery and Medicine·Cheng S Jin, Gang Zheng
Oct 10, 2006·International Journal of Food Microbiology·Stéphane GuyotPatrick Gervais
Oct 1, 1987·Journal of Microencapsulation·A RogersonA T Florence
Jul 17, 2012·International Journal of Pharmaceutics·Abdelbary M A ElhissiKevin M G Taylor
Apr 9, 2008·Biochimica Et Biophysica Acta·Mu-Ping NiehXiaoyang Qi
Jan 15, 2014·Biophysical Journal·W F Drew BennettD Peter Tieleman
Jul 9, 2002·Biochimica Et Biophysica Acta·Jesper DavidsenKent Jørgensen
Jun 10, 2016·The Journal of Physical Chemistry. B·Kleopatra EleftheriouDimitris Tsiourvas
Jul 17, 2012·Chemistry and Physics of Lipids·Elsa AbuinManuel Ahumada
Jan 1, 1990·Critical Reviews in Toxicology·B HermanJ J Lemasters
Jan 1, 1987·Critical Reviews in Biotechnology·J L MilnerJ M Wood
Jan 1, 1978·Annals of the New York Academy of Sciences·J de GierL L van Deenen
Jul 12, 1977·Biochemistry·T Y TsongM I Kanehisa
Mar 8, 1977·Biochemistry·A G Lee
Aug 28, 1984·Biochemistry·T Berclaz, M Geoffroy

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