The effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs

Bioorganic & Medicinal Chemistry Letters
Emily R JacksonCynthia S Dowd

Abstract

Inhibition of the nonmevalonate pathway (NMP) of isoprene biosynthesis has been examined as a source of new antibiotics with novel mechanisms of action. Dxr is the best studied of the NMP enzymes and several reports have described potent Dxr inhibitors. Many of these compounds are structurally related to natural products fosmidomycin and FR900098, each bearing retrohydroxamate and phosphonate groups. We synthesized a series of compounds with two to five methylene units separating these groups to examine what linker length was optimal and tested for inhibition against Mtb Dxr. We synthesized ethyl and pivaloyl esters of these compounds to increase lipophilicity and improve inhibition of Mtb growth. Our results show that propyl or propenyl linker chains are optimal. Propenyl analog 22 has an IC50 of 1.07 μM against Mtb Dxr. The pivaloyl ester of 22, compound 26, has an MIC of 9.4 μg/mL, representing a significant improvement in antitubercular potency in this class of compounds.

Citations

Aug 23, 2017·Scientific Reports·Rachel L EdwardsAudrey R Odom John
Jun 5, 2020·PLoS Pathogens·Rachel L EdwardsAudrey R Odom John
Aug 31, 2019·Future Medicinal Chemistry·Kenneth M Heidel, Cynthia S Dowd
Dec 12, 2020·European Journal of Medicinal Chemistry·Sharyu Kesharwani, Sandeep Sundriyal
Aug 17, 2021·European Journal of Medicinal Chemistry·Giulia CazzanigaStefania Villa
Oct 30, 2020·ACS Infectious Diseases·Marwa O MikatiAudrey R Odom John
Sep 8, 2018·Journal of Medicinal Chemistry·Xu WangCynthia S Dowd

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