PMID: 42637Mar 1, 1979

The effect of changes in endolymphatic ion concentrations on the tectorial membrane

Hearing Research
A Kronester-Frei

Abstract

The development of a new preparation technique has allowed the effects of fluid-substitution experiments on the tectorial membrane (t.m.) to be studied morphologically and not only, as previously, electrophysiologically. The organ of Corti and t.m. were examined in situ, unfixed and with in vivo-like ionic conditions under light-microscopical control (differential-interference-contrast, magnification 400--800X). An irreversible shrinkage of the marginal and middle zones of the t.m. was observed under the influence of Na+ ions (substitution of endolymph with artificial perilymph). This shrinkage is also seen in specimens prepared for scanning electron microscopy after perfusion of scale media with perilymph. If endolymph is replaced by an isotonic solution of EDTA (ethylenediaminetetraacetate) the t.m. can swell in its vestibulo-tympanal extent, e.g. from 39 to 72 microns. This swelling is reversible on addition of CaCl2. Although the size of the t.m. is not influenced to any great extent by changes in fluid osmolarity, reduction of H+ ion concentration leads to a minimal state of hydration of the protobril system at pH 4.3 (i.e. region of isoelectric point). The mechanism of Na+ and Ca2+ effects are discussed. These results ind...Continue Reading

References

Oct 6, 1978·Cell and Tissue Research·A Kronester-Frei
Jan 1, 1977·The Japanese Journal of Physiology·Yoshitaka TanakaY Katsuki
Nov 1, 1975·Acta Oto-laryngologica·A AxelssonB Larsson
Apr 1, 1974·The American Journal of Anatomy·M D Ross
Mar 1, 1968·The Journal of the Acoustical Society of America·T Konishi, E Kelsey
Oct 1, 1966·Acta Oto-laryngologica·T KonishiG T Singleton

Citations

Jan 1, 1980·Archives of Oto-rhino-laryngology·E K PedersenH H Elverland
Sep 11, 2004·Journal of the Association for Research in Otolaryngology : JARO·J David WoodBruce L Tempel
Sep 18, 2012·Journal of the Association for Research in Otolaryngology : JARO·Geoffrey A Manley
Jun 1, 1980·Hearing Research·J J Zwislocki
Jun 1, 1980·Hearing Research·H Duifhuis, J J van de Vorst
Mar 1, 1981·Hearing Research·H J Kraus, K Aulbach-Kraus
Nov 1, 1981·Hearing Research·L Naftalin
Apr 1, 1982·Hearing Research·W E Brownell
Mar 1, 1983·Hearing Research·K P Steel
Nov 1, 1983·Hearing Research·K P Steel
Apr 1, 1985·Hearing Research·G M Cohen, C D Fermin
Jan 1, 1986·Hearing Research·D Lim
Jan 1, 1987·Hearing Research·S E Barron, E A Daigneault
Jan 1, 1987·Hearing Research·G Runhaar, Geoffrey A Manley
Sep 15, 1988·Hearing Research·Christine Köppl
Jan 1, 1989·Hearing Research·G Runhaar
Nov 1, 1989·Hearing Research·J J Zwislocki, L K Cefaratti
Apr 1, 1990·Hearing Research·A H Gitter, H P Zenner
Jun 1, 1991·Hearing Research·B J Dannhof, V Bruns
Feb 1, 1993·Hearing Research·Dennis M FreemanThomas F Weiss
Feb 1, 1995·Hearing Research·G D Chen, P J Jastreboff
Dec 22, 2000·Hearing Research·M UlfendahlE Scarfone
Jun 5, 2003·Hearing Research·Dennis M FreemanThomas F Weiss
Jul 1, 1997·Hearing Research·K C Horner, C Aurousseau
Nov 21, 1998·Hearing Research·R M EdgeP Dallos
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·Anthony W GummerH P Zenner
Mar 7, 2003·Human Molecular Genetics·Alexander-Christian GampPaul Saftig
Apr 1, 1982·Environmental Health Perspectives·M Lawrence
Jan 10, 2012·The Journal of the Acoustical Society of America·Manuela Nowotny, Anthony W Gummer
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Manuela Nowotny, Anthony W Gummer
Jul 1, 1990·Journal of Electron Microscopy Technique·P A SantiE M Wicker
Jan 1, 1997·Progress in Histochemistry and Cytochemistry·P Gil-Loyzaga
Mar 1, 1986·American Journal of Otolaryngology·S S Orman, C D Geisler
Jan 1, 1982·American Journal of Otolaryngology·J J Zwislocki, E J Kletsky
Mar 1, 1982·American Journal of Otolaryngology·L G JohnssonJ E Hawkins
Jan 16, 2007·Hearing Research·P M SellickD Robertson
May 31, 2011·Hearing Research·Sung Huhn Kim, Daniel C Marcus
Jan 1, 1989·Acta Oto-laryngologica. Supplementum·J P Kelly
Jan 1, 1983·Audiology : Official Organ of the International Society of Audiology·J J Zwislocki
Jan 1, 1983·Audiology : Official Organ of the International Society of Audiology·R G Turner, D W Nielsen
Jan 1, 1990·Acta Oto-laryngologica·S D ComisD J Jeffries
Nov 1, 1984·Acta Oto-laryngologica·M AnnikoR Wróblewski
Jul 31, 2007·Current Biology : CB·Andrei N LukashkinIan J Russell
Apr 25, 2000·Biophysical Journal·W HemmertAnthony W Gummer
Aug 10, 2004·Biophysical Journal·Marc P Scherer, Anthony W Gummer
Jul 1, 1980·The Annals of Otology, Rhinology, and Laryngology·M Lawrence, P A Burgio
Sep 6, 2018·Cold Spring Harbor Perspectives in Medicine·Christine Köppl, Geoffrey A Manley
Mar 7, 2019·Proceedings of the National Academy of Sciences of the United States of America·Clark Elliott StrimbuAnders Fridberger
Nov 1, 1982·Acta Oto-laryngologica·G H Frommer

Related Concepts

Metazoa
Calcium
Cochlear Structure
Edetic Acid, Calcium, Sodium Salt
Endolymph
Hydrogen-Ion Concentration
Isoelectric Point
Labyrinthine Fluids
Basilar Papilla
Osmolality

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.