PMID: 11322353Apr 27, 2001Paper

The effect of changing transfusion practice on rates of perioperative stroke and myocardial infarction in patients undergoing carotid endarterectomy: a retrospective analysis of 1114 Mayo Clinic patients. Mayo Perioperative Outcomes Group

Mayo Clinic Proceedings
J R WaggonerMayo Perioperative Outcomes Group

Abstract

To evaluate changes in the institution's red blood cell (RBC) transfusion practice during the past 15 years and the influence of these changes on neurologic or cardiac morbidity after carotid endarterectomy. Based on a retrospective analysis of the Mayo Clinic database, 1,114 patients who underwent carotid endarterectomy were stratified into 1 of 2 groups: (1) 1980 to 1985 (ie, pre-human immunodeficiency virus screening, early-practice group [n=552]) and (2) 1990 to 1995 (ie, recent-practice group [n=562]). Data were compared between time periods using the chi2 test for categorical variables and the rank sum test for continuous variables. Logistic regression was used to assess the association between perioperative transfusion practice and the occurrence of stroke or myocardial infarction. Two-tailed P values < or = 05 were considered statistically significant. Patients in the recent-practice group were significantly older (mean +/- SD age, 69.6 +/- 8.7 years) vs 65.9 +/- 8.3 years in the early-practice group (P<.001). The proportion of patients receiving perioperative RBC transfusion decreased dramatically from 72.9% in 1980-1985 to 8.7% in 1990-1995 (P<.001). Additionally, the mean +/- SD number of RBC units transfused decreas...Continue Reading

References

Aug 16, 1992·The New England Journal of Medicine·J G DonahueK E Nelson
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May 1, 1991·Transfusion·S S Cook, J Epps
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Citations

Sep 19, 2002·American Journal of Therapeutics·Edward Crosby
Jun 16, 2004·Critical Care : the Official Journal of the Critical Care Forum·Samir M Fakhry, Paola Fata
Jul 24, 2012·Journal of Cardiothoracic and Vascular Anesthesia·James Y FindlayC Thomas Wass
Dec 14, 2002·Mayo Clinic Proceedings·Gregory A NuttallDavid O Warner

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