The effect of chemical sympathectomy on natural killer cells in mice

Brain, Behavior, and Immunity
A RederE Chelmicka-Schorr

Abstract

The nervous system affects immune regulation. We permanently ablated the sympathetic nervous system (SNS) of CBA mice with 6-OHDA at birth. Function of splenic natural killer (NK) cells in the sympathectomized mice was equivalent to controls at 2 weeks, but rose significantly above control levels at 4 weeks. NK cell function decreased below control values thereafter. NK cell numbers paralleled these changes in NK cell function. Our data suggest that the SNS may regulate the number and function of splenic NK cells during development.

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Citations

Jan 25, 2012·Cellular and Molecular Neurobiology·Dalay Hirsch, Zofia Zukowska
Apr 1, 1992·Journal of Neuroimmunology·G J BrennerJ A Moynihan
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