The effect of chemotherapy on health-related quality of life in mesothelioma: results from the SWAMP trial

British Journal of Cancer
D T ArnoldN A Maskell

Abstract

The effect of chemotherapy on health-related quality of life (HRQoL) in malignant pleural mesothelioma (MPM) is poorly understood. Patient-individualised prognostication and prediction of treatment response from chemotherapy is useful but little evidence exists to guide practice. Consecutive patients with MPM who were fit for first-line chemotherapy with pemetrexed and cisplatin\carboplatin were recruited and followed up for a minimum of 12 months. This study focussed on the HRQoL outcomes of these patients using the EQ-5D, EORTC QLQ-C30 and LC13. Seventy-three patients were recruited of which 58 received chemotherapy and 15 opted for best supportive care (BSC). Compliance with HRQoL questionnaires was 98% at baseline. The chemotherapy group maintained HRQoL compared with the BSC group whose overall HRQoL fell (P=0.006) with worsening dyspnoea and pain. The impact of chemotherapy was irrespective of histological subtype although those with non-epithelioid disease had worse HRQoL at later time points (P=0.012). Additionally, those with a falling mesothelin or improvement on modified-RECIST CT at early follow-up had a better HRQoL at 16 weeks. HRQoL was maintained following chemotherapy compared with a self-selected BSC group. On...Continue Reading

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Citations

Oct 24, 2017·Annals of Clinical Biochemistry·David T Arnold, Nick A Maskell
Aug 2, 2017·Occupational and Environmental Medicine·Emile TompaPaul A Demers
Mar 20, 2019·European Journal of Clinical Nutrition·Emily JefferyCarolyn J Peddle-McIntyre
Jan 19, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hedy L KindlerRaffit Hassan
Feb 9, 2017·British Journal of Cancer·David T ArnoldNick A Maskell
Jun 9, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Guillaume EberstVirginie Westeel
Feb 2, 2021·Annals of Surgical Oncology·Taylor Kantor, Elliot Wakeam
Mar 22, 2020·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Sabina Sanghera, Joanna Coast

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